DegronMD

Uniprot ID: Q9HCN4

Source protein: GPN-loop GTPase 1

Source gene: GPN1

Class: DEG_APCC_DBOX_1

Location: 288:296

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8518

ASA_SCORE: 108.4889

COIL: 0.0404

CONS_SCORE: 0.3352

DSS_SCORE: 0.5684

HELIX: 0.9611

FCONS_SCORE: 1.1725

RIG_SCORE: 0.7544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E286K	TCGA-DK-A3X1	BLCA	TCGA	QREQLERLR	DEG_APCC_DBOX_1	0.2778
p.R289C	TCGA-EO-A22U	UCEC	TCGA	QREQLERLR	DEG_APCC_DBOX_1	0.8301
p.L280P	DO230346	COCA	ICGC	QREQLERLR	DEG_APCC_DBOX_1	0.1111
p.Q288H	DO228552	LICA	ICGC	QREQLERLR	DEG_APCC_DBOX_1	0.647
p.R294L	DO229041	LICA	ICGC	QREQLERLR	DEG_APCC_DBOX_1	0.7316
p.A283T	DO232224	PBCA	ICGC	QREQLERLR	DEG_APCC_DBOX_1	0.1944
p.R294H	DO50078	UCEC	ICGC	QREQLERLR	DEG_APCC_DBOX_1	0.7133
p.R294H	ACH-001610	Brain Cancer	CCLE	QREQLERLR	DEG_APCC_DBOX_1	0.7133
p.R296Q	ACH-000785	Lung Cancer	CCLE	QREQLERLR	DEG_APCC_DBOX_1	0.6218
p.R296Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	QREQLERLR	DEG_APCC_DBOX_1	0.6218
p.R296Q	ACH-002371	Non-Cancerous	CCLE	QREQLERLR	DEG_APCC_DBOX_1	0.6218
p.E293G	ACH-000952	Prostate Cancer	CCLE	QREQLERLR	DEG_APCC_DBOX_1	0.6087
p.L295I	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	QREQLERLR	DEG_APCC_DBOX_1	0.6063
p.L283I	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	QREQLERLR	DEG_APCC_DBOX_1	0.1944
p.M299R	NCI-N87	stomach	COSMIC	QREQLERLR	DEG_APCC_DBOX_1	0.25
p.M287R	NCI-N87	stomach	COSMIC	QREQLERLR	DEG_APCC_DBOX_1	0.3056
p.S285L	KARPAS-299	haematopoietic_and_lymphoid_tissue	COSMIC	QREQLERLR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCN4	GPN-loop GTPase 1	DEG_APCC_DBOX_1	288:296	QREQLERLR	APC,CDC20,FZR1	0.8518	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons