DegronMD - Q9HCN6(GP6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P151T	TCGA-37-4130	LUSC	TCGA	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.25
p.P151T	DO26490	LUSC	ICGC	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.25
p.Y138H	TCGA-AA-3492	COAD	TCGA	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.1944
p.Y138H	DO8224	COAD	ICGC	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.1944
p.R137Q	TCGA-CM-6674	COAD	TCGA	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.1667
p.R137Q	DO10092	COAD	ICGC	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.1667
p.P157L	TCGA-DA-A95Z	SKCM	TCGA	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.0833
p.P157L	DO219481	SKCM	ICGC	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.0833
p.K155N	TCGA-EY-A1GI	UCEC	TCGA	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation substituting flanking lysine	0.25
p.K155N	DO41211	UCEC	ICGC	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation substituting flanking lysine	0.25
p.K155N	SIDM01588	Endometrial Carcinoma	GDSC	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation substituting flanking lysine	0.25
p.K155N	ACH-000993	Endometrial/Uterine Cancer	CCLE	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation substituting flanking lysine	0.25
p.Q135H	DO233226	GACA	ICGC	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.1111
p.Q142L	DO228202	LICA	ICGC	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.3056
p.P151S	DO220843	MELA	ICGC	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.25
p.K155T	SIDM01611	Endometrial Carcinoma	GDSC	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation substituting flanking lysine	0.25
p.K155T	ACH-000996	Endometrial/Uterine Cancer	CCLE	FALYKE	LIG_APCC_ABBA_1	143:148	Mutation substituting flanking lysine	0.25

Kaplan plot for GP6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GP6

UniProt ID: Q9HCN6

Entrez ID: 51206

Protein name: Platelet glycoprotein VI (GPVI) (Glycoprotein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GP6 in