DegronMD

Uniprot ID: Q9HCN6

Source protein: Platelet glycoprotein VI

Source gene: GP6

Class: LIG_APCC_ABBA_1

Location: 143:148

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5253

ASA_SCORE: 28.3833

COIL: 0.1815

CONS_SCORE: 0.6608

DSS_SCORE: 0.3396

HELIX: 0.0015

FCONS_SCORE: 1.3441

RIG_SCORE: 0.8452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P151T	TCGA-37-4130	LUSC	TCGA	FALYKE	LIG_APCC_ABBA_1	0.25
p.P151T	DO26490	LUSC	ICGC	FALYKE	LIG_APCC_ABBA_1	0.25
p.Y138H	TCGA-AA-3492	COAD	TCGA	FALYKE	LIG_APCC_ABBA_1	0.1944
p.Y138H	DO8224	COAD	ICGC	FALYKE	LIG_APCC_ABBA_1	0.1944
p.R137Q	TCGA-CM-6674	COAD	TCGA	FALYKE	LIG_APCC_ABBA_1	0.1667
p.R137Q	DO10092	COAD	ICGC	FALYKE	LIG_APCC_ABBA_1	0.1667
p.P157L	TCGA-DA-A95Z	SKCM	TCGA	FALYKE	LIG_APCC_ABBA_1	0.0833
p.P157L	DO219481	SKCM	ICGC	FALYKE	LIG_APCC_ABBA_1	0.0833
p.K155N	TCGA-EY-A1GI	UCEC	TCGA	FALYKE	LIG_APCC_ABBA_1	0.25
p.K155N	DO41211	UCEC	ICGC	FALYKE	LIG_APCC_ABBA_1	0.25
p.K155N	SIDM01588	Endometrial Carcinoma	GDSC	FALYKE	LIG_APCC_ABBA_1	0.25
p.K155N	ACH-000993	Endometrial/Uterine Cancer	CCLE	FALYKE	LIG_APCC_ABBA_1	0.25
p.Q135H	DO233226	GACA	ICGC	FALYKE	LIG_APCC_ABBA_1	0.1111
p.Q142L	DO228202	LICA	ICGC	FALYKE	LIG_APCC_ABBA_1	0.3056
p.P151S	DO220843	MELA	ICGC	FALYKE	LIG_APCC_ABBA_1	0.25
p.K155T	SIDM01611	Endometrial Carcinoma	GDSC	FALYKE	LIG_APCC_ABBA_1	0.25
p.K155T	ACH-000996	Endometrial/Uterine Cancer	CCLE	FALYKE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCN6	Platelet glycoprotein VI	LIG_APCC_ABBA_1	143:148	FALYKE	APC,CDC20,FZR1	0.5253	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons