DegronMD - Q9HCS7(XAB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q763H	TCGA-55-8205	LUAD	TCGA	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.647
p.R775L	TCGA-D3-A2JO	SKCM	TCGA	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation rewiring degron network	0.2222
p.G762W	TCGA-EE-A2MG	SKCM	TCGA	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.6714
p.G762W	SIDM00333	Endometrial Carcinoma	GDSC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.6714
p.G762W	ACH-000988	Endometrial/Uterine Cancer	CCLE	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.6714
p.G762W	MFE-319	endometrium	COSMIC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.6714
p.Q774P	TCGA-KK-A7B0	PRAD	TCGA	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation rewiring degron network	0.25
p.E779K	DO584	BLCA	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation rewiring degron network	0.1111
p.E779K	DO558	BLCA	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation rewiring degron network	0.1111
p.M769T	DO230326	COCA	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.7423
p.D767N	DO222755	COCA	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.5821
p.Q760H	DO48884	LUAD	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.7582
p.Q771P	DO219307	PRAD	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.7035
p.G759W	DO37421	SKCM	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.7825
p.R772L	DO47619	SKCM	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation rewiring degron network	0.3056
p.M766T	SIDM02021	Esophageal Carcinoma	GDSC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.6312
p.A760D	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.7793
p.A760D	ACH-000233	Lymphoma	CCLE	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.7793
p.A760D	DEL	haematopoietic and lymphoid tissue	COSMIC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	759:771	Mutation altering degron motif	0.7793

Kaplan plot for XAB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XAB2

UniProt ID: Q9HCS7

Entrez ID: 56949

Protein name: Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XAB2 in