DegronMD

Uniprot ID: Q9HCS7

Source protein: Pre-mRNA-splicing factor SYF1

Source gene: XAB2

Class: DEG_ODPH_VHL_1

Location: 759:771

E3 ligase: VHL

DEGRON score: 0.9781

ASA_SCORE: 78.3231

COIL: 0.612

CONS_SCORE: 0.2736

DSS_SCORE: 0.5571

HELIX: 0.3656

FCONS_SCORE: 1.1178

RIG_SCORE: 0.6932

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q763H	TCGA-55-8205	LUAD	TCGA	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.647
p.R775L	TCGA-D3-A2JO	SKCM	TCGA	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.2222
p.G762W	TCGA-EE-A2MG	SKCM	TCGA	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.6714
p.G762W	SIDM00333	Endometrial Carcinoma	GDSC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.6714
p.G762W	ACH-000988	Endometrial/Uterine Cancer	CCLE	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.6714
p.G762W	MFE-319	endometrium	COSMIC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.6714
p.Q774P	TCGA-KK-A7B0	PRAD	TCGA	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.25
p.E779K	DO584	BLCA	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.1111
p.E779K	DO558	BLCA	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.1111
p.M769T	DO230326	COCA	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.7423
p.D767N	DO222755	COCA	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.5821
p.Q760H	DO48884	LUAD	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.7582
p.Q771P	DO219307	PRAD	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.7035
p.G759W	DO37421	SKCM	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.7825
p.R772L	DO47619	SKCM	ICGC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.3056
p.M766T	SIDM02021	Esophageal Carcinoma	GDSC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.6312
p.A760D	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.7793
p.A760D	ACH-000233	Lymphoma	CCLE	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.7793
p.A760D	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGQSGMDDMKL	DEG_ODPH_VHL_1	0.7793

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCS7	Pre-mRNA-splicing factor SYF1	DEG_ODPH_VHL_1	759:771	LAPGQSGMDDMKL	VHL	0.9781	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons