DegronMD - Q9HD20(ATP13A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q930L	TCGA-24-0980	OV	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation altering degron motif	0.6654
p.E944G	TCGA-24-1550	OV	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1667
p.S929F	TCGA-BF-AAOX	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.3056
p.S923F	TCGA-DK-A6B6	BLCA	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1389
p.S923F	TCGA-EE-A3JA	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1389
p.S945I	TCGA-EB-A24C	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation blocking phosphorylation signal	0.5833
p.R931S	TCGA-ER-A19B	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation altering degron motif	0.7427
p.R931S	TCGA-FS-A1ZM	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation altering degron motif	0.7427
p.P921S	TCGA-FR-A729	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.0833
p.R933H	TCGA-HU-A4G9	STAD	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation altering degron motif	0.7133
p.H947N	DO228985	LICA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.0833
p.T939N	DO229026	LICA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.3056
p.V940I	DO50970	LICA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.2778
p.F948V	DO219571	LIHC	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.0556
p.N933S	DO219529	LIHC	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation altering degron motif	0.7069
p.T921N	DO50682	ORCA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.0833
p.L922F	DO219871	SKCA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1111
p.L934P	DO229234	THCA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation altering degron motif	0.7582
p.R926W	MFE-319	endometrium	COSMIC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.2222
p.R924G	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1667
p.L922I	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	QRDRLSQVL	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1111

Kaplan plot for ATP13A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP13A1

UniProt ID: Q9HD20

Entrez ID: 57130

Protein name: Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP13A1 in