DegronMD

Uniprot ID: Q9HD20

Source protein: Endoplasmic reticulum transmembrane helix translocase

Source gene: ATP13A1

Class: DEG_APCC_DBOX_1

Location: 930:938

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7995

ASA_SCORE: 65.9778

COIL: 0.0408

CONS_SCORE: 0.4073

DSS_SCORE: 0.687

HELIX: 0.9591

FCONS_SCORE: 1.1105

RIG_SCORE: 0.7208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q930L	TCGA-24-0980	OV	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	0.6654
p.E944G	TCGA-24-1550	OV	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	0.1667
p.S929F	TCGA-BF-AAOX	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	0.3056
p.S923F	TCGA-DK-A6B6	BLCA	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	0.1389
p.S923F	TCGA-EE-A3JA	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	0.1389
p.S945I	TCGA-EB-A24C	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	0.5833
p.R931S	TCGA-ER-A19B	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	0.7427
p.R931S	TCGA-FS-A1ZM	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	0.7427
p.P921S	TCGA-FR-A729	SKCM	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	0.0833
p.R933H	TCGA-HU-A4G9	STAD	TCGA	QRDRLSQVL	DEG_APCC_DBOX_1	0.7133
p.H947N	DO228985	LICA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	0.0833
p.T939N	DO229026	LICA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	0.3056
p.V940I	DO50970	LICA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	0.2778
p.F948V	DO219571	LIHC	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	0.0556
p.N933S	DO219529	LIHC	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	0.7069
p.T921N	DO50682	ORCA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	0.0833
p.L922F	DO219871	SKCA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	0.1111
p.L934P	DO229234	THCA	ICGC	QRDRLSQVL	DEG_APCC_DBOX_1	0.7582
p.R926W	MFE-319	endometrium	COSMIC	QRDRLSQVL	DEG_APCC_DBOX_1	0.2222
p.R924G	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	QRDRLSQVL	DEG_APCC_DBOX_1	0.1667
p.L922I	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	QRDRLSQVL	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HD20	Endoplasmic reticulum transmembrane helix translocase	DEG_APCC_DBOX_1	930:938	QRDRLSQVL	APC,CDC20,FZR1	0.7995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons