DegronMD - Q9HD43(PTPRH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W228R	TCGA-05-4424	LUAD	TCGA	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.W228R	DO23672	LUAD	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.P210Q	TCGA-29-1763	OV	TCGA	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.P210Q	DO28422	OV	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.H208P	TCGA-AA-3952	COAD	TCGA	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0556
p.H208P	DO10341	COAD	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0556
p.V211A	TCGA-AA-A022	COAD	TCGA	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.V211A	DO10647	COAD	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.Q219H	TCGA-CQ-7071	HNSC	TCGA	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.647
p.Q219H	DO49069	HNSC	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.647
p.S222R	TCGA-DX-A6YS	SARC	TCGA	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7427
p.S222R	DO229022	LICA	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7427
p.S222R	DO220005	SARC	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7427
p.E217K	TCGA-ER-A19E	SKCM	TCGA	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.E217K	DO47542	SKCM	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.V211L	DO23818	LUAD	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.A218V	DO232224	PBCA	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.5825
p.A225T	DO36881	READ	ICGC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.25
p.P231L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.P231L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.P231L	ACH-000995	Leukemia	CCLE	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.P231L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.E217Q	SIDM00875	Breast Carcinoma	GDSC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.E217Q	ACH-000624	Breast Cancer	CCLE	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.E217Q	HCC1806	breast	COSMIC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.A218S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7588
p.A218S	ACH-002222	Leukemia	CCLE	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7588
p.A218S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7588
p.R212S	ACH-001344	Neuroblastoma	CCLE	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.S223F	ACH-002396	Bone Cancer	CCLE	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.S223F	Sarc9371	bone	COSMIC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.Q219E	H513	pleura	COSMIC	AQTTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.5633

Kaplan plot for PTPRH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRH

UniProt ID: Q9HD43

Entrez ID: 5794

Protein name: Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPRH in