DegronMD

Uniprot ID: Q9HD43

Source protein: Receptor-type tyrosine-protein phosphatase H

Source gene: PTPRH

Class: DEG_SPOP_SBC_1

Location: 218:222

E3 ligase: SPOP

DEGRON score: 0.7243

ASA_SCORE: 62.78

COIL: 0.5566

CONS_SCORE: 0.2806

DSS_SCORE: 0.4693

HELIX: 0.0108

FCONS_SCORE: 1.0325

RIG_SCORE: 0.7386

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W228R	TCGA-05-4424	LUAD	TCGA	AQTTS	DEG_SPOP_SBC_1	0.1667
p.W228R	DO23672	LUAD	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1667
p.P210Q	TCGA-29-1763	OV	TCGA	AQTTS	DEG_SPOP_SBC_1	0.1111
p.P210Q	DO28422	OV	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1111
p.H208P	TCGA-AA-3952	COAD	TCGA	AQTTS	DEG_SPOP_SBC_1	0.0556
p.H208P	DO10341	COAD	ICGC	AQTTS	DEG_SPOP_SBC_1	0.0556
p.V211A	TCGA-AA-A022	COAD	TCGA	AQTTS	DEG_SPOP_SBC_1	0.1389
p.V211A	DO10647	COAD	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1389
p.Q219H	TCGA-CQ-7071	HNSC	TCGA	AQTTS	DEG_SPOP_SBC_1	0.647
p.Q219H	DO49069	HNSC	ICGC	AQTTS	DEG_SPOP_SBC_1	0.647
p.S222R	TCGA-DX-A6YS	SARC	TCGA	AQTTS	DEG_SPOP_SBC_1	0.7427
p.S222R	DO229022	LICA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.7427
p.S222R	DO220005	SARC	ICGC	AQTTS	DEG_SPOP_SBC_1	0.7427
p.E217K	TCGA-ER-A19E	SKCM	TCGA	AQTTS	DEG_SPOP_SBC_1	0.3056
p.E217K	DO47542	SKCM	ICGC	AQTTS	DEG_SPOP_SBC_1	0.3056
p.V211L	DO23818	LUAD	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1389
p.A218V	DO232224	PBCA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.5825
p.A225T	DO36881	READ	ICGC	AQTTS	DEG_SPOP_SBC_1	0.25
p.P231L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AQTTS	DEG_SPOP_SBC_1	0.0833
p.P231L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	AQTTS	DEG_SPOP_SBC_1	0.0833
p.P231L	ACH-000995	Leukemia	CCLE	AQTTS	DEG_SPOP_SBC_1	0.0833
p.P231L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	AQTTS	DEG_SPOP_SBC_1	0.0833
p.E217Q	SIDM00875	Breast Carcinoma	GDSC	AQTTS	DEG_SPOP_SBC_1	0.3056
p.E217Q	ACH-000624	Breast Cancer	CCLE	AQTTS	DEG_SPOP_SBC_1	0.3056
p.E217Q	HCC1806	breast	COSMIC	AQTTS	DEG_SPOP_SBC_1	0.3056
p.A218S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	AQTTS	DEG_SPOP_SBC_1	0.7588
p.A218S	ACH-002222	Leukemia	CCLE	AQTTS	DEG_SPOP_SBC_1	0.7588
p.A218S	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	AQTTS	DEG_SPOP_SBC_1	0.7588
p.R212S	ACH-001344	Neuroblastoma	CCLE	AQTTS	DEG_SPOP_SBC_1	0.1667
p.S223F	ACH-002396	Bone Cancer	CCLE	AQTTS	DEG_SPOP_SBC_1	0.3056
p.S223F	Sarc9371	bone	COSMIC	AQTTS	DEG_SPOP_SBC_1	0.3056
p.Q219E	H513	pleura	COSMIC	AQTTS	DEG_SPOP_SBC_1	0.5633

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15366	Poly	DEG_SPOP_SBC_1	285:289	AQTTS	SPOP	0.9033	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3456:3460	AQTTS	SPOP	0.9192	More...
Q9HD43	Receptor-type tyrosine-protein phosphatase H	DEG_SPOP_SBC_1	218:222	AQTTS	SPOP	0.7243	More...
Q9UBN7	Histone deacetylase 6	DEG_SPOP_SBC_1	991:995	AQTTS	SPOP	0.6571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AQTTS

Degron related mutations and impact score

Drug responses associated with PTPRH mutations

All proteins holding degron of AQTTS