DegronMD

Uniprot ID: Q9UBN7

Source protein: Histone deacetylase 6

Source gene: HDAC6

Class: DEG_SPOP_SBC_1

Location: 991:995

E3 ligase: SPOP

DEGRON score: 0.6571

ASA_SCORE: 76.08

COIL: 0.546

CONS_SCORE: 0.341

DSS_SCORE: 0.6128

HELIX: 0.3756

FCONS_SCORE: 0.9845

RIG_SCORE: 0.7581

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A984V	TCGA-AG-3906	READ	TCGA	AQTTS	DEG_SPOP_SBC_1	0.1389
p.S995L	TCGA-C5-A2M2	CESC	TCGA	AQTTS	DEG_SPOP_SBC_1	0.8778
p.T993S	TCGA-EW-A6SD	BRCA	TCGA	AQTTS	DEG_SPOP_SBC_1	0.7116
p.A988T	TCGA-HU-A4GQ	STAD	TCGA	AQTTS	DEG_SPOP_SBC_1	0.25
p.D983Y	DO228974	LICA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1111
p.G987R	DO229052	LICA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.2222
p.G987R	DO50970	LICA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.2222
p.G1000V	DO28952	OV	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1944
p.A998V	DO36491	READ	ICGC	AQTTS	DEG_SPOP_SBC_1	0.25
p.A1002T	DO47767	STAD	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1389

Drug responses associated with HDAC6 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00474	OV\|ovary	p.G1083D (No)	GDSC	ACY-1215	15.9017
SIDM00474	OV\|ovary	p.G1083D (No)	GDSC	Tubastatin A	179.1729
SIDM00474	OV\|ovary	p.G1083D (No)	GDSC	CAY10603	2.1391
SIDM00720	MESO\|mesothelioma	p.G73A (No)	GDSC	ACY-1215	28.5016
SIDM00720	MESO\|mesothelioma	p.G73A (No)	GDSC	Tubastatin A	322.5893
SIDM00720	MESO\|mesothelioma	p.G73A (No)	GDSC	CAY10603	20.7166
SIDM00720	MESO\|mesothelioma	p.G73A (No)	GDSC	PCI-34051	69.842
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R243H (No)	GDSC	ACY-1215	1.7539
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R243H (No)	GDSC	Tubastatin A	24.8929
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R243H (No)	GDSC	CAY10603	1.1244
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R243H (No)	GDSC	PCI-34051	6.4577
SIDM01031	ESCA\|oesophagus	p.S1068F (No)	GDSC	ACY-1215	4.5664
SIDM01031	ESCA\|oesophagus	p.S1068F (No)	GDSC	Tubastatin A	116.9837
SIDM01031	ESCA\|oesophagus	p.S1068F (No)	GDSC	CAY10603	9.6304
SIDM00688	DLBC\|B_cell_lymphoma	p.E779Q (No)	GDSC	ACY-1215	0.6815
SIDM00688	DLBC\|B_cell_lymphoma	p.E779Q (No)	GDSC	Tubastatin A	6.6212
SIDM00688	DLBC\|B_cell_lymphoma	p.E779Q (No)	GDSC	CAY10603	0.2114
SIDM00688	DLBC\|B_cell_lymphoma	p.E779Q (No)	GDSC	PCI-34051	125.69
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.L199M (No)	GDSC	ACY-1215	0.6334
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.L199M (No)	GDSC	Tubastatin A	4.0395
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.L199M (No)	GDSC	CAY10603	0.1265
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.L199M (No)	GDSC	PCI-34051	16.217
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.A234T (No)	GDSC	ACY-1215	2.555
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.A234T (No)	GDSC	Tubastatin A	13.5763
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.A234T (No)	GDSC	CAY10603	0.5268
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.A234T (No)	GDSC	PCI-34051	19.359
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.S563T (No)	GDSC	ACY-1215	0.8592
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.S563T (No)	GDSC	Tubastatin A	5.0336
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.S563T (No)	GDSC	CAY10603	0.3046
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.S563T (No)	GDSC	PCI-34051	8.0886
SIDM00782	COREAD\|large_intestine	p.G521R (No)	GDSC	ACY-1215	151.1623
SIDM00782	COREAD\|large_intestine	p.G521R (No)	GDSC	Tubastatin A	159.1185
SIDM00782	COREAD\|large_intestine	p.G521R (No)	GDSC	CAY10603	4.3813
SIDM00782	COREAD\|large_intestine	p.G521R (No)	GDSC	PCI-34051	285.31
SIDM00272	BRCA\|breast	p.P1123A (No)	GDSC	ACY-1215	0.6983
SIDM00272	BRCA\|breast	p.P1123A (No)	GDSC	Tubastatin A	12.7498
SIDM00272	BRCA\|breast	p.P1123A (No)	GDSC	CAY10603	0.4193
SIDM00272	BRCA\|breast	p.P1123A (No)	GDSC	PCI-34051	82.6
SIDM00272	BRCA\|breast	p.P1123L (No)	GDSC	ACY-1215	0.6983
SIDM00272	BRCA\|breast	p.P1123L (No)	GDSC	Tubastatin A	12.7498
SIDM00272	BRCA\|breast	p.P1123L (No)	GDSC	CAY10603	0.4193
SIDM00272	BRCA\|breast	p.P1123L (No)	GDSC	PCI-34051	82.6
SIDM00095	GBM\|glioma	p.R835Q (No)	GDSC	ACY-1215	20.7226
SIDM00095	GBM\|glioma	p.R835Q (No)	GDSC	Tubastatin A	174.8646
SIDM00095	GBM\|glioma	p.R835Q (No)	GDSC	CAY10603	3.8567
SIDM00818	KIRC\|kidney	p.G1083D (No)	GDSC	ACY-1215	4.2083
SIDM00818	KIRC\|kidney	p.G1083D (No)	GDSC	Tubastatin A	76.314
SIDM00818	KIRC\|kidney	p.G1083D (No)	GDSC	CAY10603	0.5486
SIDM00045	STAD\|stomach	p.R418W (No)	GDSC	ACY-1215	1.9413
SIDM00045	STAD\|stomach	p.R418W (No)	GDSC	Tubastatin A	13.3707
SIDM00174	HNSC\|head_and_neck	p.Y1149* (No)	GDSC	ACY-1215	353.8054
SIDM00174	HNSC\|head_and_neck	p.Y1149* (No)	GDSC	Tubastatin A	294.0356
SIDM00174	HNSC\|head_and_neck	p.Y1149* (No)	GDSC	CAY10603	15.7163
SIDM00174	HNSC\|head_and_neck	p.Y1149* (No)	GDSC	PCI-34051	42.952
SIDM00781	COREAD\|large_intestine	p.W474* (No)	GDSC	ACY-1215	4.138
SIDM00781	COREAD\|large_intestine	p.W474* (No)	GDSC	Tubastatin A	130.6284
SIDM00781	COREAD\|large_intestine	p.W474* (No)	GDSC	CAY10603	1.9858
SIDM00781	COREAD\|large_intestine	p.W474* (No)	GDSC	PCI-34051	85.412
SIDM00974	SKCM\|melanoma	p.S1089L (No)	GDSC	ACY-1215	2.0901
SIDM00974	SKCM\|melanoma	p.S1089L (No)	GDSC	Tubastatin A	19.398
SIDM00974	SKCM\|melanoma	p.S1089L (No)	GDSC	CAY10603	0.6933
SIDM00974	SKCM\|melanoma	p.S1089L (No)	GDSC	PCI-34051	44.879
SIDM01174	CESC\|cervix	p.L59P (No)	GDSC	ACY-1215	4.0522
SIDM01174	CESC\|cervix	p.L59P (No)	GDSC	Tubastatin A	394.775
SIDM01174	CESC\|cervix	p.L59P (No)	GDSC	CAY10603	8.7628
SIDM01174	CESC\|cervix	p.L59P (No)	GDSC	PCI-34051	777.17
SIDM01051	UNCLASSIFIED\|ovary	p.A612T (No)	GDSC	ACY-1215	4.5611
SIDM01051	UNCLASSIFIED\|ovary	p.A612T (No)	GDSC	Tubastatin A	42.3745
SIDM01051	UNCLASSIFIED\|ovary	p.A612T (No)	GDSC	CAY10603	1.27
SIDM01051	UNCLASSIFIED\|ovary	p.A612T (No)	GDSC	PCI-34051	41.494
SIDM00971	BRCA\|breast	p.V1151I (No)	GDSC	PCI-34051	618.5
SIDM01088	UNCLASSIFIED\|endometrium	p.R835W (No)	GDSC	ACY-1215	3.1979
SIDM01088	UNCLASSIFIED\|endometrium	p.R835W (No)	GDSC	Tubastatin A	172.9693
SIDM01088	UNCLASSIFIED\|endometrium	p.R835W (No)	GDSC	CAY10603	0.7694
SIDM01088	UNCLASSIFIED\|endometrium	p.R835W (No)	GDSC	PCI-34051	56.434
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.A586S (No)	GDSC	PCI-34051	252.16
SIDM00220	OV\|ovary	p.A770V (No)	GDSC	ACY-1215	6.8847
SIDM00220	OV\|ovary	p.A770V (No)	GDSC	Tubastatin A	101.3265
SIDM00220	OV\|ovary	p.A770V (No)	GDSC	CAY10603	2.1649
SIDM00982	GBM\|glioma	p.S12Y (No)	GDSC	ACY-1215	10.916
SIDM00982	GBM\|glioma	p.S12Y (No)	GDSC	Tubastatin A	113.286
SIDM00982	GBM\|glioma	p.S12Y (No)	GDSC	CAY10603	3.1066
SIDM00982	GBM\|glioma	p.S12Y (No)	GDSC	PCI-34051	129.01
SIDM00331	UNCLASSIFIED\|B_cell_leukemia	p.G1083D (No)	GDSC	PCI-34051	2.0974
SIDM01092	STAD\|stomach	p.T1099I (No)	GDSC	ACY-1215	12.1642
SIDM01092	STAD\|stomach	p.T1099I (No)	GDSC	Tubastatin A	23.6548
SIDM01092	STAD\|stomach	p.T1099I (No)	GDSC	CAY10603	0.1683
SIDM01092	STAD\|stomach	p.T1099I (No)	GDSC	PCI-34051	30.884
SIDM01092	STAD\|stomach	p.N1200D (No)	GDSC	ACY-1215	12.1642
SIDM01092	STAD\|stomach	p.N1200D (No)	GDSC	Tubastatin A	23.6548
SIDM01092	STAD\|stomach	p.N1200D (No)	GDSC	CAY10603	0.1683
SIDM01092	STAD\|stomach	p.N1200D (No)	GDSC	PCI-34051	30.884
SIDM00217	COREAD\|large_intestine	p.R529H (No)	GDSC	ACY-1215	4.4312
SIDM00217	COREAD\|large_intestine	p.R529H (No)	GDSC	Tubastatin A	544.786
SIDM00217	COREAD\|large_intestine	p.R529H (No)	GDSC	CAY10603	4.9354
SIDM00217	COREAD\|large_intestine	p.R529H (No)	GDSC	PCI-34051	159.72
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.Q487K (No)	GDSC	ACY-1215	0.8791
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.Q487K (No)	GDSC	Tubastatin A	6.1081
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.Q487K (No)	GDSC	CAY10603	0.162
SIDM00216	COREAD\|large_intestine	p.A617T (No)	GDSC	ACY-1215	3.2916
SIDM00216	COREAD\|large_intestine	p.A617T (No)	GDSC	Tubastatin A	151.8407
SIDM00216	COREAD\|large_intestine	p.A617T (No)	GDSC	CAY10603	0.8666
SIDM00216	COREAD\|large_intestine	p.A617T (No)	GDSC	PCI-34051	148.06
SIDM00282	COREAD\|large_intestine	p.I1122V (No)	GDSC	ACY-1215	172.264
SIDM00282	COREAD\|large_intestine	p.I1122V (No)	GDSC	Tubastatin A	188.5089
SIDM00282	COREAD\|large_intestine	p.I1122V (No)	GDSC	CAY10603	3.6479
SIDM00282	COREAD\|large_intestine	p.I1122V (No)	GDSC	PCI-34051	70.698
SIDM00882	BRCA\|breast	p.N1200D (No)	GDSC	ACY-1215	1.5407
SIDM00882	BRCA\|breast	p.N1200D (No)	GDSC	Tubastatin A	150.3061
SIDM00882	BRCA\|breast	p.N1200D (No)	GDSC	CAY10603	8.3222
SIDM00882	BRCA\|breast	p.N1200D (No)	GDSC	PCI-34051	117.24
SIDM01140	UNCLASSIFIED\|ovary	p.N1200D (No)	GDSC	ACY-1215	0.4919
SIDM01140	UNCLASSIFIED\|ovary	p.N1200D (No)	GDSC	Tubastatin A	3.9419
SIDM01140	UNCLASSIFIED\|ovary	p.N1200D (No)	GDSC	CAY10603	0.1288
SIDM01140	UNCLASSIFIED\|ovary	p.N1200D (No)	GDSC	PCI-34051	5.4627
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G1126C (No)	GDSC	ACY-1215	1.3909
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G1126C (No)	GDSC	Tubastatin A	19.1397
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G1126C (No)	GDSC	CAY10603	0.665
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G1126C (No)	GDSC	PCI-34051	123.11
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.E436D (No)	GDSC	ACY-1215	2.3066
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.E436D (No)	GDSC	Tubastatin A	100.7282
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.E436D (No)	GDSC	CAY10603	149.21
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.E436D (No)	GDSC	PCI-34051	8.6508
SIDM00627	CESC\|cervix	p.I1177F (No)	GDSC	ACY-1215	4.0417
SIDM00627	CESC\|cervix	p.I1177F (No)	GDSC	Tubastatin A	283.6069
SIDM00627	CESC\|cervix	p.I1177F (No)	GDSC	CAY10603	1.9604
SIDM00627	CESC\|cervix	p.I1177F (No)	GDSC	PCI-34051	152.34
SIDM00487	COREAD\|large_intestine	p.L119P (No)	GDSC	ACY-1215	2.7707
SIDM00487	COREAD\|large_intestine	p.L119P (No)	GDSC	Tubastatin A	101.8288
SIDM00487	COREAD\|large_intestine	p.L119P (No)	GDSC	CAY10603	1.1616
SIDM00487	COREAD\|large_intestine	p.L119P (No)	GDSC	PCI-34051	132.12
SIDM00217	COREAD\|large_intestine	p.P1033fs*17 (No)	GDSC	ACY-1215	4.4312
SIDM00217	COREAD\|large_intestine	p.P1033fs*17 (No)	GDSC	Tubastatin A	544.786
SIDM00217	COREAD\|large_intestine	p.P1033fs*17 (No)	GDSC	CAY10603	4.9354
SIDM00217	COREAD\|large_intestine	p.P1033fs*17 (No)	GDSC	PCI-34051	159.72
SIDM00490	GBM\|glioma	p.P748T (No)	GDSC	ACY-1215	7.7926
SIDM00490	GBM\|glioma	p.P748T (No)	GDSC	Tubastatin A	294.4302
SIDM00490	GBM\|glioma	p.P748T (No)	GDSC	CAY10603	2.9709
SIDM00490	GBM\|glioma	p.P748T (No)	GDSC	PCI-34051	241.42
SIDM01027	ESCA\|oesophagus	p.P45S (No)	GDSC	ACY-1215	6.3158
SIDM01027	ESCA\|oesophagus	p.P45S (No)	GDSC	Tubastatin A	191.9233
SIDM01027	ESCA\|oesophagus	p.P45S (No)	GDSC	CAY10603	4.3607
SIDM01027	ESCA\|oesophagus	p.P45S (No)	GDSC	PCI-34051	67.364
SIDM00374	DLBC\|B_cell_lymphoma	p.R835Q (No)	GDSC	ACY-1215	1.5713
SIDM00374	DLBC\|B_cell_lymphoma	p.R835Q (No)	GDSC	Tubastatin A	21.2676
SIDM00374	DLBC\|B_cell_lymphoma	p.R835Q (No)	GDSC	CAY10603	0.2122
SIDM00374	DLBC\|B_cell_lymphoma	p.R835Q (No)	GDSC	PCI-34051	14.268
SIDM00481	OV\|ovary	p.I1177F (No)	GDSC	ACY-1215	4.7578
SIDM00481	OV\|ovary	p.I1177F (No)	GDSC	Tubastatin A	209.1199
SIDM00481	OV\|ovary	p.I1177F (No)	GDSC	CAY10603	0.5911
SIDM00481	OV\|ovary	p.I1177F (No)	GDSC	PCI-34051	476.97
SIDM00054	PAAD\|pancreas	p.P1033S (No)	GDSC	ACY-1215	12.494
SIDM00054	PAAD\|pancreas	p.P1033S (No)	GDSC	Tubastatin A	262.0732
SIDM00054	PAAD\|pancreas	p.P1033S (No)	GDSC	CAY10603	4.1045
SIDM00054	PAAD\|pancreas	p.P1033S (No)	GDSC	PCI-34051	369.49

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15366	Poly	DEG_SPOP_SBC_1	285:289	AQTTS	SPOP	0.9033	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3456:3460	AQTTS	SPOP	0.9192	More...
Q9HD43	Receptor-type tyrosine-protein phosphatase H	DEG_SPOP_SBC_1	218:222	AQTTS	SPOP	0.7243	More...
Q9UBN7	Histone deacetylase 6	DEG_SPOP_SBC_1	991:995	AQTTS	SPOP	0.6571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AQTTS

Degron related mutations and impact score

Drug responses associated with HDAC6 mutations

All proteins holding degron of AQTTS