DegronMD

Uniprot ID: Q15366

Source protein: Poly

Source gene: PCBP2

Class: DEG_SPOP_SBC_1

Location: 285:289

E3 ligase: SPOP

DEGRON score: 0.9033

ASA_SCORE: 60.76

COIL: 0.6266

CONS_SCORE: 0.3446

DSS_SCORE: 0.3255

HELIX: 0.0722

FCONS_SCORE: 0.7902

RIG_SCORE: 0.7478

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S290Y	TCGA-BS-A0UF	UCEC	TCGA	AQTTS	DEG_SPOP_SBC_1	0.3056
p.S296Y	DO52596	BOCA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1389
p.S294L	DO222363	MELA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1944
p.S294L	DO37635	SKCM	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1944
p.S294L	DO47631	SKCM	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1944
p.A275V	DO51545	PACA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.0556
p.A280V	DO229229	THCA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1944
p.V291F	DO41253	UCEC	ICGC	AQTTS	DEG_SPOP_SBC_1	0.2778
p.S296T	DO42472	UCEC	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1389
p.L282V	SIDM00118	Colorectal Carcinoma	GDSC	AQTTS	DEG_SPOP_SBC_1	0.25
p.L282V	HCC2998	large_intestine	COSMIC	AQTTS	DEG_SPOP_SBC_1	0.25
p.L278V	ACH-001081	Colon/Colorectal Cancer	CCLE	AQTTS	DEG_SPOP_SBC_1	0.5833
p.L278V	HCC2998	large_intestine	COSMIC	AQTTS	DEG_SPOP_SBC_1	0.5833
p.L281V	HCC2998	large_intestine	COSMIC	AQTTS	DEG_SPOP_SBC_1	0.2222
p.L277V	HCC2998	large_intestine	COSMIC	AQTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15366	Poly	DEG_SPOP_SBC_1	285:289	AQTTS	SPOP	0.9033	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3456:3460	AQTTS	SPOP	0.9192	More...
Q9HD43	Receptor-type tyrosine-protein phosphatase H	DEG_SPOP_SBC_1	218:222	AQTTS	SPOP	0.7243	More...
Q9UBN7	Histone deacetylase 6	DEG_SPOP_SBC_1	991:995	AQTTS	SPOP	0.6571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons