DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 3456:3460

E3 ligase: SPOP

DEGRON score: 0.9192

ASA_SCORE: 91.24

COIL: 0.8466

CONS_SCORE: 0

DSS_SCORE: 0.3609

HELIX: 0.0234

FCONS_SCORE: 0

RIG_SCORE: 0.8004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3449I	TCGA-A5-A1OF	UCEC	TCGA	AQTTS	DEG_SPOP_SBC_1	0.1389
p.T3449I	DO42568	UCEC	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1389
p.G3467R	TCGA-D3-A8GI	SKCM	TCGA	AQTTS	DEG_SPOP_SBC_1	0.1389
p.G3467R	DO50284	SKCM	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1389
p.G3470C	TCGA-DF-A2KU	UCEC	TCGA	AQTTS	DEG_SPOP_SBC_1	0.0556
p.G3470C	DO223286	UCEC	ICGC	AQTTS	DEG_SPOP_SBC_1	0.0556
p.S3466F	TCGA-EB-A3Y7	SKCM	TCGA	AQTTS	DEG_SPOP_SBC_1	0.1667
p.S3466F	DO37499	SKCM	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1667
p.G3467A	TCGA-FD-A3NA	BLCA	TCGA	AQTTS	DEG_SPOP_SBC_1	0.1389
p.G3467A	DO602	BLCA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1389
p.T3458I	TCGA-L5-A8NR	ESCA	TCGA	AQTTS	DEG_SPOP_SBC_1	0.7078
p.D3468E	TCGA-UB-A7MB	LIHC	TCGA	AQTTS	DEG_SPOP_SBC_1	0.1111
p.D3468E	DO52318	LIHC	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1111
p.Q3469K	DO228126	EOPC	ICGC	AQTTS	DEG_SPOP_SBC_1	0.0833
p.P3465S	DO220877	MELA	ICGC	AQTTS	DEG_SPOP_SBC_1	0.1944
p.T3459S	SIDM00761	Small Cell Lung Carcinoma	GDSC	AQTTS	DEG_SPOP_SBC_1	0.6005
p.T3459S	ACH-000752	Lung Cancer	CCLE	AQTTS	DEG_SPOP_SBC_1	0.6005
p.T3459S	NCI-H196	lung	COSMIC	AQTTS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15366	Poly	DEG_SPOP_SBC_1	285:289	AQTTS	SPOP	0.9033	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3456:3460	AQTTS	SPOP	0.9192	More...
Q9HD43	Receptor-type tyrosine-protein phosphatase H	DEG_SPOP_SBC_1	218:222	AQTTS	SPOP	0.7243	More...
Q9UBN7	Histone deacetylase 6	DEG_SPOP_SBC_1	991:995	AQTTS	SPOP	0.6571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons