DegronMD - Q9UBN7(HDAC6)

GO - Biological processes (BP): aggresome assembly [GO:0070842]; autophagy [GO:0006914]; axonal transport of mitochondrion [GO:0019896]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to misfolded protein [GO:0071218]; cellular response to topologically incorrect protein [GO:0035967]; cilium assembly [GO:0060271]; collateral sprouting [GO:0048668]; dendritic spine morphogenesis [GO:0060997]; histone deacetylation [GO:0016575]; Hsp90 deacetylation [GO:0070846]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of proteolysis [GO:0045861]; negative regulation of transcription, DNA-templated [GO:0045892]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; peptidyl-lysine deacetylation [GO:0034983]; polyubiquitinated misfolded protein transport [GO:0070845]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of signaling receptor activity [GO:2000273]; protein-containing complex disassembly [GO:0032984]; protein deacetylation [GO:0006476]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of establishment of protein localization [GO:0070201]; regulation of fat cell differentiation [GO:0045598]; regulation of gene expression, epigenetic [GO:0040029]; regulation of macroautophagy [GO:0016241]; regulation of microtubule-based movement [GO:0060632]; regulation of protein stability [GO:0031647]; response to growth factor [GO:0070848]; response to misfolded protein [GO:0051788]; tubulin deacetylation [GO:0090042]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A984V	TCGA-AG-3906	READ	TCGA	AQTTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.1389
p.A1012V	TCGA-AJ-A3EL	UCEC	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1667
p.P1013T	TCGA-AP-A056	UCEC	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1944
p.Q1030H	TCGA-AP-A1DV	UCEC	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1944
p.E1017K	TCGA-BS-A0UV	UCEC	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.3056
p.G1014W	TCGA-C4-A0F1	BLCA	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.2222
p.S995L	TCGA-C5-A2M2	CESC	TCGA	AQTTS	DEG_SPOP_SBC_1	991:995	Mutation altering degron motif	0.8778
p.T993S	TCGA-EW-A6SD	BRCA	TCGA	AQTTS	DEG_SPOP_SBC_1	991:995	Mutation altering degron motif	0.7116
p.G1014R	TCGA-G4-6293	COAD	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.2222
p.A988T	TCGA-HU-A4GQ	STAD	TCGA	AQTTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.25
p.S1035L	TCGA-O2-A5IB	LUSC	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation blocking phosphorylation signal	0.5
p.G1028W	DO581	BLCA	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.25
p.S1009L	DO48984	CESC	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.0833
p.G1028R	DO10405	COAD	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.25
p.D983Y	DO228974	LICA	ICGC	AQTTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.1111
p.G987R	DO229052	LICA	ICGC	AQTTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.2222
p.G987R	DO50970	LICA	ICGC	AQTTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.2222
p.G1000V	DO28952	OV	ICGC	AQTTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.1944
p.A998V	DO36491	READ	ICGC	AQTTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.25
p.A1002T	DO47767	STAD	ICGC	AQTTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.1389
p.A1026V	DO41542	UCEC	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.3056
p.E1031K	DO42793	UCEC	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation blocking phosphorylation signal	0.6111
p.P1027T	DO43971	UCEC	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation blocking phosphorylation signal	0.7222
p.S1025L	SIDM01015	Chronic Myelogenous Leukemia	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.7667
p.S1025L	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.7667
p.S1025L	SIDM01148	Plasma Cell Myeloma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.7667
p.S1025L	SIDM00522	Small Cell Lung Carcinoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.7667
p.S1025L	SIDM01160	Bladder Carcinoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.7667
p.S1025L	SIDM01757	Bladder Carcinoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.7667
p.S1025L	SIDM01766	Chondrosarcoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.7667
p.P1033S	SIDM00054	Pancreatic Carcinoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1033S	ACH-001619	Gallbladder Cancer	CCLE	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1033S	ACH-002185	Pancreatic Cancer	CCLE	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.P1033S	PL18	pancreas	COSMIC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1111
p.I1019V	ACH-001569	Skin Cancer	CCLE	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation altering degron motif	0.5965
p.S1034L	WM35	skin	COSMIC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation blocking phosphorylation signal	0.5278
p.S1013F	KYSE-150	oesophagus	COSMIC	LIQTPLAS	DEG_SCF_FBW7_1	1018:1025	Mutation rewiring degron network	0.1944

Kaplan plot for HDAC6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HDAC6

UniProt ID: Q9UBN7

Entrez ID: 10013

Protein name: Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HDAC6 in