DegronMD

Uniprot ID: Q9UBN7

Source protein: Histone deacetylase 6

Source gene: HDAC6

Class: DEG_SCF_FBW7_1

Location: 1018:1025

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 75.8375

COIL: 0.7079

CONS_SCORE: 0.3401

DSS_SCORE: 0.8151

HELIX: 0.0746

FCONS_SCORE: 1.0273

RIG_SCORE: 0.6761

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1012V	TCGA-AJ-A3EL	UCEC	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	0.1667
p.P1013T	TCGA-AP-A056	UCEC	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	0.1944
p.Q1030H	TCGA-AP-A1DV	UCEC	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	0.1944
p.E1017K	TCGA-BS-A0UV	UCEC	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	0.3056
p.G1014W	TCGA-C4-A0F1	BLCA	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	0.2222
p.G1014R	TCGA-G4-6293	COAD	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	0.2222
p.S1035L	TCGA-O2-A5IB	LUSC	TCGA	LIQTPLAS	DEG_SCF_FBW7_1	0.5
p.G1028W	DO581	BLCA	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	0.25
p.S1009L	DO48984	CESC	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	0.0833
p.G1028R	DO10405	COAD	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	0.25
p.A1026V	DO41542	UCEC	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	0.3056
p.E1031K	DO42793	UCEC	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	0.6111
p.P1027T	DO43971	UCEC	ICGC	LIQTPLAS	DEG_SCF_FBW7_1	0.7222
p.S1025L	SIDM01015	Chronic Myelogenous Leukemia	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	0.7667
p.S1025L	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	0.7667
p.S1025L	SIDM01148	Plasma Cell Myeloma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	0.7667
p.S1025L	SIDM00522	Small Cell Lung Carcinoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	0.7667
p.S1025L	SIDM01160	Bladder Carcinoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	0.7667
p.S1025L	SIDM01757	Bladder Carcinoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	0.7667
p.S1025L	SIDM01766	Chondrosarcoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	0.7667
p.P1033S	SIDM00054	Pancreatic Carcinoma	GDSC	LIQTPLAS	DEG_SCF_FBW7_1	0.1111
p.P1033S	ACH-001619	Gallbladder Cancer	CCLE	LIQTPLAS	DEG_SCF_FBW7_1	0.1111
p.P1033S	ACH-002185	Pancreatic Cancer	CCLE	LIQTPLAS	DEG_SCF_FBW7_1	0.1111
p.P1033S	PL18	pancreas	COSMIC	LIQTPLAS	DEG_SCF_FBW7_1	0.1111
p.I1019V	ACH-001569	Skin Cancer	CCLE	LIQTPLAS	DEG_SCF_FBW7_1	0.5965
p.S1034L	WM35	skin	COSMIC	LIQTPLAS	DEG_SCF_FBW7_1	0.5278
p.S1013F	KYSE-150	oesophagus	COSMIC	LIQTPLAS	DEG_SCF_FBW7_1	0.1944

Drug responses associated with HDAC6 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00474	OV\|ovary	p.G1083D (No)	GDSC	ACY-1215	15.9017
SIDM00474	OV\|ovary	p.G1083D (No)	GDSC	Tubastatin A	179.1729
SIDM00474	OV\|ovary	p.G1083D (No)	GDSC	CAY10603	2.1391
SIDM00720	MESO\|mesothelioma	p.G73A (No)	GDSC	ACY-1215	28.5016
SIDM00720	MESO\|mesothelioma	p.G73A (No)	GDSC	Tubastatin A	322.5893
SIDM00720	MESO\|mesothelioma	p.G73A (No)	GDSC	CAY10603	20.7166
SIDM00720	MESO\|mesothelioma	p.G73A (No)	GDSC	PCI-34051	69.842
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R243H (No)	GDSC	ACY-1215	1.7539
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R243H (No)	GDSC	Tubastatin A	24.8929
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R243H (No)	GDSC	CAY10603	1.1244
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R243H (No)	GDSC	PCI-34051	6.4577
SIDM01031	ESCA\|oesophagus	p.S1068F (No)	GDSC	ACY-1215	4.5664
SIDM01031	ESCA\|oesophagus	p.S1068F (No)	GDSC	Tubastatin A	116.9837
SIDM01031	ESCA\|oesophagus	p.S1068F (No)	GDSC	CAY10603	9.6304
SIDM00688	DLBC\|B_cell_lymphoma	p.E779Q (No)	GDSC	ACY-1215	0.6815
SIDM00688	DLBC\|B_cell_lymphoma	p.E779Q (No)	GDSC	Tubastatin A	6.6212
SIDM00688	DLBC\|B_cell_lymphoma	p.E779Q (No)	GDSC	CAY10603	0.2114
SIDM00688	DLBC\|B_cell_lymphoma	p.E779Q (No)	GDSC	PCI-34051	125.69
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.L199M (No)	GDSC	ACY-1215	0.6334
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.L199M (No)	GDSC	Tubastatin A	4.0395
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.L199M (No)	GDSC	CAY10603	0.1265
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.L199M (No)	GDSC	PCI-34051	16.217
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.A234T (No)	GDSC	ACY-1215	2.555
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.A234T (No)	GDSC	Tubastatin A	13.5763
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.A234T (No)	GDSC	CAY10603	0.5268
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.A234T (No)	GDSC	PCI-34051	19.359
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.S563T (No)	GDSC	ACY-1215	0.8592
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.S563T (No)	GDSC	Tubastatin A	5.0336
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.S563T (No)	GDSC	CAY10603	0.3046
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.S563T (No)	GDSC	PCI-34051	8.0886
SIDM00782	COREAD\|large_intestine	p.G521R (No)	GDSC	ACY-1215	151.1623
SIDM00782	COREAD\|large_intestine	p.G521R (No)	GDSC	Tubastatin A	159.1185
SIDM00782	COREAD\|large_intestine	p.G521R (No)	GDSC	CAY10603	4.3813
SIDM00782	COREAD\|large_intestine	p.G521R (No)	GDSC	PCI-34051	285.31
SIDM00272	BRCA\|breast	p.P1123A (No)	GDSC	ACY-1215	0.6983
SIDM00272	BRCA\|breast	p.P1123A (No)	GDSC	Tubastatin A	12.7498
SIDM00272	BRCA\|breast	p.P1123A (No)	GDSC	CAY10603	0.4193
SIDM00272	BRCA\|breast	p.P1123A (No)	GDSC	PCI-34051	82.6
SIDM00272	BRCA\|breast	p.P1123L (No)	GDSC	ACY-1215	0.6983
SIDM00272	BRCA\|breast	p.P1123L (No)	GDSC	Tubastatin A	12.7498
SIDM00272	BRCA\|breast	p.P1123L (No)	GDSC	CAY10603	0.4193
SIDM00272	BRCA\|breast	p.P1123L (No)	GDSC	PCI-34051	82.6
SIDM00095	GBM\|glioma	p.R835Q (No)	GDSC	ACY-1215	20.7226
SIDM00095	GBM\|glioma	p.R835Q (No)	GDSC	Tubastatin A	174.8646
SIDM00095	GBM\|glioma	p.R835Q (No)	GDSC	CAY10603	3.8567
SIDM00818	KIRC\|kidney	p.G1083D (No)	GDSC	ACY-1215	4.2083
SIDM00818	KIRC\|kidney	p.G1083D (No)	GDSC	Tubastatin A	76.314
SIDM00818	KIRC\|kidney	p.G1083D (No)	GDSC	CAY10603	0.5486
SIDM00045	STAD\|stomach	p.R418W (No)	GDSC	ACY-1215	1.9413
SIDM00045	STAD\|stomach	p.R418W (No)	GDSC	Tubastatin A	13.3707
SIDM00174	HNSC\|head_and_neck	p.Y1149* (No)	GDSC	ACY-1215	353.8054
SIDM00174	HNSC\|head_and_neck	p.Y1149* (No)	GDSC	Tubastatin A	294.0356
SIDM00174	HNSC\|head_and_neck	p.Y1149* (No)	GDSC	CAY10603	15.7163
SIDM00174	HNSC\|head_and_neck	p.Y1149* (No)	GDSC	PCI-34051	42.952
SIDM00781	COREAD\|large_intestine	p.W474* (No)	GDSC	ACY-1215	4.138
SIDM00781	COREAD\|large_intestine	p.W474* (No)	GDSC	Tubastatin A	130.6284
SIDM00781	COREAD\|large_intestine	p.W474* (No)	GDSC	CAY10603	1.9858
SIDM00781	COREAD\|large_intestine	p.W474* (No)	GDSC	PCI-34051	85.412
SIDM00974	SKCM\|melanoma	p.S1089L (No)	GDSC	ACY-1215	2.0901
SIDM00974	SKCM\|melanoma	p.S1089L (No)	GDSC	Tubastatin A	19.398
SIDM00974	SKCM\|melanoma	p.S1089L (No)	GDSC	CAY10603	0.6933
SIDM00974	SKCM\|melanoma	p.S1089L (No)	GDSC	PCI-34051	44.879
SIDM01174	CESC\|cervix	p.L59P (No)	GDSC	ACY-1215	4.0522
SIDM01174	CESC\|cervix	p.L59P (No)	GDSC	Tubastatin A	394.775
SIDM01174	CESC\|cervix	p.L59P (No)	GDSC	CAY10603	8.7628
SIDM01174	CESC\|cervix	p.L59P (No)	GDSC	PCI-34051	777.17
SIDM01051	UNCLASSIFIED\|ovary	p.A612T (No)	GDSC	ACY-1215	4.5611
SIDM01051	UNCLASSIFIED\|ovary	p.A612T (No)	GDSC	Tubastatin A	42.3745
SIDM01051	UNCLASSIFIED\|ovary	p.A612T (No)	GDSC	CAY10603	1.27
SIDM01051	UNCLASSIFIED\|ovary	p.A612T (No)	GDSC	PCI-34051	41.494
SIDM00971	BRCA\|breast	p.V1151I (No)	GDSC	PCI-34051	618.5
SIDM01088	UNCLASSIFIED\|endometrium	p.R835W (No)	GDSC	ACY-1215	3.1979
SIDM01088	UNCLASSIFIED\|endometrium	p.R835W (No)	GDSC	Tubastatin A	172.9693
SIDM01088	UNCLASSIFIED\|endometrium	p.R835W (No)	GDSC	CAY10603	0.7694
SIDM01088	UNCLASSIFIED\|endometrium	p.R835W (No)	GDSC	PCI-34051	56.434
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.A586S (No)	GDSC	PCI-34051	252.16
SIDM00220	OV\|ovary	p.A770V (No)	GDSC	ACY-1215	6.8847
SIDM00220	OV\|ovary	p.A770V (No)	GDSC	Tubastatin A	101.3265
SIDM00220	OV\|ovary	p.A770V (No)	GDSC	CAY10603	2.1649
SIDM00982	GBM\|glioma	p.S12Y (No)	GDSC	ACY-1215	10.916
SIDM00982	GBM\|glioma	p.S12Y (No)	GDSC	Tubastatin A	113.286
SIDM00982	GBM\|glioma	p.S12Y (No)	GDSC	CAY10603	3.1066
SIDM00982	GBM\|glioma	p.S12Y (No)	GDSC	PCI-34051	129.01
SIDM00331	UNCLASSIFIED\|B_cell_leukemia	p.G1083D (No)	GDSC	PCI-34051	2.0974
SIDM01092	STAD\|stomach	p.T1099I (No)	GDSC	ACY-1215	12.1642
SIDM01092	STAD\|stomach	p.T1099I (No)	GDSC	Tubastatin A	23.6548
SIDM01092	STAD\|stomach	p.T1099I (No)	GDSC	CAY10603	0.1683
SIDM01092	STAD\|stomach	p.T1099I (No)	GDSC	PCI-34051	30.884
SIDM01092	STAD\|stomach	p.N1200D (No)	GDSC	ACY-1215	12.1642
SIDM01092	STAD\|stomach	p.N1200D (No)	GDSC	Tubastatin A	23.6548
SIDM01092	STAD\|stomach	p.N1200D (No)	GDSC	CAY10603	0.1683
SIDM01092	STAD\|stomach	p.N1200D (No)	GDSC	PCI-34051	30.884
SIDM00217	COREAD\|large_intestine	p.R529H (No)	GDSC	ACY-1215	4.4312
SIDM00217	COREAD\|large_intestine	p.R529H (No)	GDSC	Tubastatin A	544.786
SIDM00217	COREAD\|large_intestine	p.R529H (No)	GDSC	CAY10603	4.9354
SIDM00217	COREAD\|large_intestine	p.R529H (No)	GDSC	PCI-34051	159.72
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.Q487K (No)	GDSC	ACY-1215	0.8791
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.Q487K (No)	GDSC	Tubastatin A	6.1081
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.Q487K (No)	GDSC	CAY10603	0.162
SIDM00216	COREAD\|large_intestine	p.A617T (No)	GDSC	ACY-1215	3.2916
SIDM00216	COREAD\|large_intestine	p.A617T (No)	GDSC	Tubastatin A	151.8407
SIDM00216	COREAD\|large_intestine	p.A617T (No)	GDSC	CAY10603	0.8666
SIDM00216	COREAD\|large_intestine	p.A617T (No)	GDSC	PCI-34051	148.06
SIDM00282	COREAD\|large_intestine	p.I1122V (No)	GDSC	ACY-1215	172.264
SIDM00282	COREAD\|large_intestine	p.I1122V (No)	GDSC	Tubastatin A	188.5089
SIDM00282	COREAD\|large_intestine	p.I1122V (No)	GDSC	CAY10603	3.6479
SIDM00282	COREAD\|large_intestine	p.I1122V (No)	GDSC	PCI-34051	70.698
SIDM00882	BRCA\|breast	p.N1200D (No)	GDSC	ACY-1215	1.5407
SIDM00882	BRCA\|breast	p.N1200D (No)	GDSC	Tubastatin A	150.3061
SIDM00882	BRCA\|breast	p.N1200D (No)	GDSC	CAY10603	8.3222
SIDM00882	BRCA\|breast	p.N1200D (No)	GDSC	PCI-34051	117.24
SIDM01140	UNCLASSIFIED\|ovary	p.N1200D (No)	GDSC	ACY-1215	0.4919
SIDM01140	UNCLASSIFIED\|ovary	p.N1200D (No)	GDSC	Tubastatin A	3.9419
SIDM01140	UNCLASSIFIED\|ovary	p.N1200D (No)	GDSC	CAY10603	0.1288
SIDM01140	UNCLASSIFIED\|ovary	p.N1200D (No)	GDSC	PCI-34051	5.4627
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G1126C (No)	GDSC	ACY-1215	1.3909
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G1126C (No)	GDSC	Tubastatin A	19.1397
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G1126C (No)	GDSC	CAY10603	0.665
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G1126C (No)	GDSC	PCI-34051	123.11
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.E436D (No)	GDSC	ACY-1215	2.3066
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.E436D (No)	GDSC	Tubastatin A	100.7282
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.E436D (No)	GDSC	CAY10603	149.21
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.E436D (No)	GDSC	PCI-34051	8.6508
SIDM00627	CESC\|cervix	p.I1177F (No)	GDSC	ACY-1215	4.0417
SIDM00627	CESC\|cervix	p.I1177F (No)	GDSC	Tubastatin A	283.6069
SIDM00627	CESC\|cervix	p.I1177F (No)	GDSC	CAY10603	1.9604
SIDM00627	CESC\|cervix	p.I1177F (No)	GDSC	PCI-34051	152.34
SIDM00487	COREAD\|large_intestine	p.L119P (No)	GDSC	ACY-1215	2.7707
SIDM00487	COREAD\|large_intestine	p.L119P (No)	GDSC	Tubastatin A	101.8288
SIDM00487	COREAD\|large_intestine	p.L119P (No)	GDSC	CAY10603	1.1616
SIDM00487	COREAD\|large_intestine	p.L119P (No)	GDSC	PCI-34051	132.12
SIDM00217	COREAD\|large_intestine	p.P1033fs*17 (Yes)	GDSC	ACY-1215	4.4312
SIDM00217	COREAD\|large_intestine	p.P1033fs*17 (Yes)	GDSC	Tubastatin A	544.786
SIDM00217	COREAD\|large_intestine	p.P1033fs*17 (Yes)	GDSC	CAY10603	4.9354
SIDM00217	COREAD\|large_intestine	p.P1033fs*17 (Yes)	GDSC	PCI-34051	159.72
SIDM00490	GBM\|glioma	p.P748T (No)	GDSC	ACY-1215	7.7926
SIDM00490	GBM\|glioma	p.P748T (No)	GDSC	Tubastatin A	294.4302
SIDM00490	GBM\|glioma	p.P748T (No)	GDSC	CAY10603	2.9709
SIDM00490	GBM\|glioma	p.P748T (No)	GDSC	PCI-34051	241.42
SIDM01027	ESCA\|oesophagus	p.P45S (No)	GDSC	ACY-1215	6.3158
SIDM01027	ESCA\|oesophagus	p.P45S (No)	GDSC	Tubastatin A	191.9233
SIDM01027	ESCA\|oesophagus	p.P45S (No)	GDSC	CAY10603	4.3607
SIDM01027	ESCA\|oesophagus	p.P45S (No)	GDSC	PCI-34051	67.364
SIDM00374	DLBC\|B_cell_lymphoma	p.R835Q (No)	GDSC	ACY-1215	1.5713
SIDM00374	DLBC\|B_cell_lymphoma	p.R835Q (No)	GDSC	Tubastatin A	21.2676
SIDM00374	DLBC\|B_cell_lymphoma	p.R835Q (No)	GDSC	CAY10603	0.2122
SIDM00374	DLBC\|B_cell_lymphoma	p.R835Q (No)	GDSC	PCI-34051	14.268
SIDM00481	OV\|ovary	p.I1177F (No)	GDSC	ACY-1215	4.7578
SIDM00481	OV\|ovary	p.I1177F (No)	GDSC	Tubastatin A	209.1199
SIDM00481	OV\|ovary	p.I1177F (No)	GDSC	CAY10603	0.5911
SIDM00481	OV\|ovary	p.I1177F (No)	GDSC	PCI-34051	476.97
SIDM00054	PAAD\|pancreas	p.P1033S (Yes)	GDSC	ACY-1215	12.494
SIDM00054	PAAD\|pancreas	p.P1033S (Yes)	GDSC	Tubastatin A	262.0732
SIDM00054	PAAD\|pancreas	p.P1033S (Yes)	GDSC	CAY10603	4.1045
SIDM00054	PAAD\|pancreas	p.P1033S (Yes)	GDSC	PCI-34051	369.49

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LIQTPLAS

Degron related mutations and impact score

Drug responses associated with HDAC6 mutations

All proteins holding degron of LIQTPLAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBN7	Histone deacetylase 6	DEG_SCF_FBW7_1	1018:1025	LIQTPLAS	FBXW7	0.9958	More...