DegronMD - Q9HD90(NEUROD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D268Y	TCGA-AX-A0J0	UCEC	TCGA	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.0556
p.D268Y	DO41133	UCEC	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.0556
p.P255S	TCGA-BS-A0TA	UCEC	TCGA	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation altering degron motif	0.6752
p.P255S	DO43298	UCEC	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation altering degron motif	0.6752
p.S260N	TCGA-D1-A17D	UCEC	TCGA	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.2778
p.S260N	DO41746	UCEC	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.2778
p.S260N	SIDM00976	Melanoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.2778
p.S260N	ACH-002205	Skin Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.2778
p.S260N	WM1552C	skin	COSMIC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.2778
p.S245N	TCGA-EE-A180	SKCM	TCGA	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.S245N	DO47537	SKCM	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.S245N	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.S245N	SIDM01257	Hepatocellular Carcinoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.S245N	SIDM00062	Hepatocellular Carcinoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.S245N	ACH-000671	Liver Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.S245N	ACH-000858	Lung Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.S245N	ACH-002395	Liver Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.S245N	HUH-6-clone5	liver	COSMIC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.S245N	KNS-62	lung	COSMIC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.G251S	TCGA-EE-A3AA	SKCM	TCGA	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.3056
p.G251S	DO222632	MELA	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.3056
p.G251S	DO37571	SKCM	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.3056
p.C244Y	TCGA-EY-A215	UCEC	TCGA	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1111
p.C244Y	DO42665	UCEC	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1111
p.F263V	TCGA-L5-A88V	ESCA	TCGA	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1944
p.Q267H	DO233906	GACA	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.0833
p.L265F	DO229032	LICA	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1389
p.S260I	DO229038	LICA	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.2778
p.T246A	DO50796	LIRI	ICGC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.1667
p.Y249C	SIDM01573	Plasma Cell Myeloma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.25
p.Y249C	ACH-000576	Myeloma	CCLE	PLTPPLS	DEG_SCF_FBW7_1	252:258	Mutation rewiring degron network	0.25

Kaplan plot for NEUROD4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEUROD4

UniProt ID: Q9HD90

Entrez ID: 58158

Protein name: Neurogenic differentiation factor 4 (NeuroD4) (Class A basic helix-loop-helix protein 4) (bHLHa4) (Protein atonal homolog 3) (ATH-3) (Atoh3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEUROD4 in