DegronMD

Uniprot ID: Q9HD90

Source protein: Neurogenic differentiation factor 4

Source gene: NEUROD4

Class: DEG_SCF_FBW7_1

Location: 252:258

E3 ligase: FBXW7

DEGRON score: 0.9662

ASA_SCORE: 58.5571

COIL: 0.8387

CONS_SCORE: 0.4434

DSS_SCORE: 0.5368

HELIX: 0.0236

FCONS_SCORE: 1.0533

RIG_SCORE: 0.6829

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D268Y	TCGA-AX-A0J0	UCEC	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.0556
p.D268Y	DO41133	UCEC	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.0556
p.P255S	TCGA-BS-A0TA	UCEC	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.6752
p.P255S	DO43298	UCEC	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.6752
p.S260N	TCGA-D1-A17D	UCEC	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.S260N	DO41746	UCEC	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.S260N	SIDM00976	Melanoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.S260N	ACH-002205	Skin Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.S260N	WM1552C	skin	COSMIC	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.S245N	TCGA-EE-A180	SKCM	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	DO47537	SKCM	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	SIDM01257	Hepatocellular Carcinoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	SIDM00062	Hepatocellular Carcinoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	ACH-000671	Liver Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	ACH-000858	Lung Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	ACH-002395	Liver Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	HUH-6-clone5	liver	COSMIC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	KNS-62	lung	COSMIC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.G251S	TCGA-EE-A3AA	SKCM	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.3056
p.G251S	DO222632	MELA	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.3056
p.G251S	DO37571	SKCM	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.3056
p.C244Y	TCGA-EY-A215	UCEC	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.1111
p.C244Y	DO42665	UCEC	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.1111
p.F263V	TCGA-L5-A88V	ESCA	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.1944
p.Q267H	DO233906	GACA	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.0833
p.L265F	DO229032	LICA	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S260I	DO229038	LICA	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.T246A	DO50796	LIRI	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.1667
p.Y249C	SIDM01573	Plasma Cell Myeloma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	0.25
p.Y249C	ACH-000576	Myeloma	CCLE	PLTPPLS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTPPLS

Degron related mutations and impact score

Drug responses associated with NEUROD4 mutations

All proteins holding degron of PLTPPLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HD90	Neurogenic differentiation factor 4	DEG_SCF_FBW7_1	252:258	PLTPPLS	FBXW7	0.9662	More...