DegronMD

Uniprot ID: Q9HD90

Source protein: Neurogenic differentiation factor 4

Source gene: NEUROD4

Class: DEG_SCF_FBW7_1

Location: 252:258

E3 ligase: FBXW7

DEGRON score: 0.9662

ASA_SCORE: 58.5571

COIL: 0.8387

CONS_SCORE: 0.4434

DSS_SCORE: 0.5368

HELIX: 0.0236

FCONS_SCORE: 1.0533

RIG_SCORE: 0.6829

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P255S	TCGA-BS-A0TA	UCEC	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.6752
p.P255S	DO43298	UCEC	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.6752
p.G251S	TCGA-EE-A3AA	SKCM	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.3056
p.G251S	DO222632	MELA	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.3056
p.G251S	DO37571	SKCM	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.3056
p.S260N	TCGA-D1-A17D	UCEC	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.S260N	DO41746	UCEC	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.S260N	SIDM00976	Melanoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.S260N	ACH-002205	Skin Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.S260N	WM1552C	skin	COSMIC	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.S260I	DO229038	LICA	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.2778
p.Y249C	SIDM01573	Plasma Cell Myeloma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	0.25
p.Y249C	ACH-000576	Myeloma	CCLE	PLTPPLS	DEG_SCF_FBW7_1	0.25
p.F263V	TCGA-L5-A88V	ESCA	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.1944
p.T246A	DO50796	LIRI	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.1667
p.S245N	TCGA-EE-A180	SKCM	TCGA	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	DO47537	SKCM	ICGC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	SIDM01257	Hepatocellular Carcinoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	SIDM00062	Hepatocellular Carcinoma	GDSC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	ACH-000671	Liver Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	ACH-000858	Lung Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	ACH-002395	Liver Cancer	CCLE	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	HUH-6-clone5	liver	COSMIC	PLTPPLS	DEG_SCF_FBW7_1	0.1389
p.S245N	KNS-62	lung	COSMIC	PLTPPLS	DEG_SCF_FBW7_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HD90	Neurogenic differentiation factor 4	DEG_SCF_FBW7_1	252:258	PLTPPLS	FBXW7	0.9662	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons