DegronMD - Q9NP31(SH2D2A)

SH2D2A

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A171S	TCGA-AP-A1DK	UCEC	TCGA	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.2222
p.L168R	DO44117	BRCA	ICGC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.1389
p.E183K	DO25797	LUAD	ICGC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.25
p.E184Q	DO26469	LUSC	ICGC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.2222
p.G177E	DO27271	LUSC	ICGC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.7199
p.P173S	DO219878	SKCA	ICGC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.2778
p.A176V	DO48009	STAD	ICGC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.6936
p.L178P	DO38211	STAD	ICGC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.7582
p.R181M	DO43306	UCEC	ICGC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.3056
p.Q171H	DO43578	UCEC	ICGC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.2222
p.E183G	DO41871	UCEC	ICGC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.25
p.P173H	MFE-319	endometrium	COSMIC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.2778
p.F187I	IGROV-1	ovary	COSMIC	LSPYGE	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc