DegronMD

Uniprot ID: Q9NP31

Source protein: SH2 domain-containing protein 2A

Source gene: SH2D2A

Class: LIG_APCC_ABBA_1

Location: 175:180

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9732

ASA_SCORE: 56.3167

COIL: 0.8732

CONS_SCORE: 0.5466

DSS_SCORE: 0.4375

HELIX: 0.0615

FCONS_SCORE: 1.2742

RIG_SCORE: 0.6623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A171S	TCGA-AP-A1DK	UCEC	TCGA	LSPYGE	LIG_APCC_ABBA_1	0.2222
p.L168R	DO44117	BRCA	ICGC	LSPYGE	LIG_APCC_ABBA_1	0.1389
p.E183K	DO25797	LUAD	ICGC	LSPYGE	LIG_APCC_ABBA_1	0.25
p.E184Q	DO26469	LUSC	ICGC	LSPYGE	LIG_APCC_ABBA_1	0.2222
p.G177E	DO27271	LUSC	ICGC	LSPYGE	LIG_APCC_ABBA_1	0.7199
p.P173S	DO219878	SKCA	ICGC	LSPYGE	LIG_APCC_ABBA_1	0.2778
p.A176V	DO48009	STAD	ICGC	LSPYGE	LIG_APCC_ABBA_1	0.6936
p.L178P	DO38211	STAD	ICGC	LSPYGE	LIG_APCC_ABBA_1	0.7582
p.R181M	DO43306	UCEC	ICGC	LSPYGE	LIG_APCC_ABBA_1	0.3056
p.Q171H	DO43578	UCEC	ICGC	LSPYGE	LIG_APCC_ABBA_1	0.2222
p.E183G	DO41871	UCEC	ICGC	LSPYGE	LIG_APCC_ABBA_1	0.25
p.P173H	MFE-319	endometrium	COSMIC	LSPYGE	LIG_APCC_ABBA_1	0.2778
p.F187I	IGROV-1	ovary	COSMIC	LSPYGE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NP31	SH2 domain-containing protein 2A	LIG_APCC_ABBA_1	175:180	LSPYGE	APC,CDC20,FZR1	0.9732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons