DegronMD - Q9NP71(MLXIPL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R579W	TCGA-06-0649	GBM	TCGA	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation rewiring degron network	0.25
p.R579W	DO11142	GBM	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation rewiring degron network	0.25
p.P571S	TCGA-14-1450	GBM	TCGA	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.5641
p.P571S	DO13270	GBM	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.5641
p.P570R	TCGA-77-8144	LUSC	TCGA	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.6401
p.P570R	DO26949	LUSC	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.6401
p.P570S	TCGA-BS-A0UV	UCEC	TCGA	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.5641
p.P570S	DO42793	UCEC	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.5641
p.G583C	DO230342	COCA	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation rewiring degron network	0.1389
p.P570L	DO220873	MELA	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.6471
p.P570L	DO46838	RECA	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.6471
p.T572P	DO227681	SKCA	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.7031
p.L569P	SIDM00285	Neuroblastoma	GDSC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.6471
p.C566S	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation rewiring degron network	0.25
p.C566S	ACH-000945	Lung Cancer	CCLE	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation rewiring degron network	0.25
p.C566S	NCI-H650	lung	COSMIC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation rewiring degron network	0.25
p.T572N	SIDM01107	Melanoma	GDSC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation altering degron motif	0.7055
p.A563T	EFO-27	ovary	COSMIC	LPPTPAPT	DEG_SCF_FBW7_1	569:576	Mutation rewiring degron network	0.1667

Kaplan plot for MLXIPL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MLXIPL

UniProt ID: Q9NP71

Entrez ID: 51085

Protein name: Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MLXIPL in