DegronMD

Uniprot ID: Q9NP71

Source protein: Carbohydrate-responsive element-binding protein

Source gene: MLXIPL

Class: DEG_SCF_FBW7_1

Location: 569:576

E3 ligase: FBXW7

DEGRON score: 0.8802

ASA_SCORE: 94.4375

COIL: 0.9773

CONS_SCORE: 0.4169

DSS_SCORE: 0.6841

HELIX: 0.0058

FCONS_SCORE: 0.9874

RIG_SCORE: 0.5804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R579W	TCGA-06-0649	GBM	TCGA	LPPTPAPT	DEG_SCF_FBW7_1	0.25
p.R579W	DO11142	GBM	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	0.25
p.P571S	TCGA-14-1450	GBM	TCGA	LPPTPAPT	DEG_SCF_FBW7_1	0.5641
p.P571S	DO13270	GBM	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	0.5641
p.P570R	TCGA-77-8144	LUSC	TCGA	LPPTPAPT	DEG_SCF_FBW7_1	0.6401
p.P570R	DO26949	LUSC	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	0.6401
p.P570S	TCGA-BS-A0UV	UCEC	TCGA	LPPTPAPT	DEG_SCF_FBW7_1	0.5641
p.P570S	DO42793	UCEC	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	0.5641
p.G583C	DO230342	COCA	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	0.1389
p.P570L	DO220873	MELA	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	0.6471
p.P570L	DO46838	RECA	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	0.6471
p.T572P	DO227681	SKCA	ICGC	LPPTPAPT	DEG_SCF_FBW7_1	0.7031
p.L569P	SIDM00285	Neuroblastoma	GDSC	LPPTPAPT	DEG_SCF_FBW7_1	0.6471
p.C566S	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LPPTPAPT	DEG_SCF_FBW7_1	0.25
p.C566S	ACH-000945	Lung Cancer	CCLE	LPPTPAPT	DEG_SCF_FBW7_1	0.25
p.C566S	NCI-H650	lung	COSMIC	LPPTPAPT	DEG_SCF_FBW7_1	0.25
p.T572N	SIDM01107	Melanoma	GDSC	LPPTPAPT	DEG_SCF_FBW7_1	0.7055
p.A563T	EFO-27	ovary	COSMIC	LPPTPAPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13118	Krueppel-like factor 10	DEG_SCF_FBW7_1	472:479	LPPTPAPT	FBXW7	0.9926	More...
Q9NP71	Carbohydrate-responsive element-binding protein	DEG_SCF_FBW7_1	569:576	LPPTPAPT	FBXW7	0.8802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons