DegronMD - Q13118(KLF10)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L467V	TCGA-21-5783	LUSC	TCGA	LPPTPAPT	DEG_SCF_FBW7_1	472:479	Mutation rewiring degron network	0.1944
p.S97N	TCGA-2W-A8YY	CESC	TCGA	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation altering degron motif	0.818
p.S465I	TCGA-AP-A0LM	UCEC	TCGA	LPPTPAPT	DEG_SCF_FBW7_1	472:479	Mutation rewiring degron network	0.1389
p.P94A	TCGA-CV-7414	HNSC	TCGA	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation altering degron motif	0.7503
p.P82R	TCGA-DD-AADP	LIHC	TCGA	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation rewiring degron network	0.0556
p.A195V	TCGA-EO-A22U	UCEC	TCGA	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.1944
p.S88F	DO48414	BLCA	ICGC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation rewiring degron network	0.2222
p.D210H	DO2216	BRCA	ICGC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.2778
p.S86N	DO223732	CESC	ICGC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation rewiring degron network	0.1667
p.P83A	DO15631	HNSC	ICGC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation rewiring degron network	0.0833
p.C201Y	DO50898	LICA	ICGC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation altering degron motif	0.7087
p.S214I	DO23320	LINC	ICGC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.1667
p.D208A	DO23398	LINC	ICGC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation altering degron motif	0.7793
p.Y218H	DO45317	LUAD	ICGC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.0556
p.H107L	DO231132	LUSC	ICGC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation rewiring degron network	0.0556
p.S104A	DO26701	LUSC	ICGC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation rewiring degron network	0.1389
p.A102E	DO230449	UTCA	ICGC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation rewiring degron network	0.1944
p.R197I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.25
p.R197I	ACH-002256	Leukemia	CCLE	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.25
p.R197I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.25
p.L92F	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation altering degron motif	0.6981
p.L92F	ACH-000583	Lymphoma	CCLE	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation altering degron motif	0.6981
p.L92F	MC116	haematopoietic and lymphoid tissue	COSMIC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation altering degron motif	0.6981
p.E194K	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.1667
p.E194K	ACH-000886	Lung Cancer	CCLE	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.1667
p.E194K	NCI-H2009	lung	COSMIC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.1667
p.A203V	SIDM00954	Breast Carcinoma	GDSC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation altering degron motif	0.6936
p.A203V	ACH-001820	Breast Cancer	CCLE	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation altering degron motif	0.6936
p.A203V	COLO-824	breast	COSMIC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation altering degron motif	0.6936
p.P95H	SIDM00986	Head and Neck Carcinoma	GDSC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation altering degron motif	0.6583
p.P95H	ACH-000548	Head and Neck Cancer	CCLE	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation altering degron motif	0.6583
p.P95H	BHY	upper aerodigestive tract	COSMIC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation altering degron motif	0.6583
p.T93N	SIDM01612	Endometrial Carcinoma	GDSC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation altering degron motif	0.8166
p.T93N	ACH-000946	Endometrial/Uterine Cancer	CCLE	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation altering degron motif	0.8166
p.N199T	ACH-000973	Bladder Cancer	CCLE	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.3056
p.V217M	ACH-001767	Non-Cancerous	CCLE	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.0833
p.D83N	ACH-001852	Bile Duct Cancer	CCLE	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation rewiring degron network	0.0833
p.P84H	BHY	upper aerodigestive tract	COSMIC	LTPPYS	DEG_SCF_FBW7_1	92:97	Mutation rewiring degron network	0.1111
p.A213T	HEC-1	endometrium	COSMIC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.1944
p.A192V	COLO-824	breast	COSMIC	IPCAAVSPN	DEG_SIAH_1	200:208	Mutation rewiring degron network	0.1111

Kaplan plot for KLF10 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLF10

UniProt ID: Q13118

Entrez ID: 7071

Protein name: Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KLF10 in