DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LPPTPAPT
Uniprot ID:
Q13118
Source protein:
Krueppel-like factor 10
Source gene:
KLF10
Class:
DEG_SCF_FBW7_1
Location:
472:479
E3 ligase:
FBXW7
DEGRON score:
0.9926
ASA_SCORE:
95.9125
COIL:
0.944
CONS_SCORE:
0.5444
DSS_SCORE:
0.8213
HELIX:
0.0428
FCONS_SCORE:
1.1089
RIG_SCORE:
0.6587
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L467V
TCGA-21-5783
LUSC
TCGA
LPPTPAPT
DEG_SCF_FBW7_1
0.1944
p.S465I
TCGA-AP-A0LM
UCEC
TCGA
LPPTPAPT
DEG_SCF_FBW7_1
0.1389
Drug responses associated with KLF10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPPTPAPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13118
Krueppel-like factor 10
DEG_SCF_FBW7_1
472:479
LPPTPAPT
FBXW7
0.9926
More...
Q9NP71
Carbohydrate-responsive element-binding protein
DEG_SCF_FBW7_1
569:576
LPPTPAPT
FBXW7
0.8802
More...