DegronMD

Uniprot ID: Q13118

Source protein: Krueppel-like factor 10

Source gene: KLF10

Class: DEG_SCF_FBW7_1

Location: 92:97

E3 ligase: FBXW7

DEGRON score: 0.9996

ASA_SCORE: 75.9333

COIL: 0.9663

CONS_SCORE: 0.5306

DSS_SCORE: 0.4094

HELIX: 0.0063

FCONS_SCORE: 1.1135

RIG_SCORE: 0.7069

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S97N	TCGA-2W-A8YY	CESC	TCGA	LTPPYS	DEG_SCF_FBW7_1	0.818
p.P94A	TCGA-CV-7414	HNSC	TCGA	LTPPYS	DEG_SCF_FBW7_1	0.7503
p.P82R	TCGA-DD-AADP	LIHC	TCGA	LTPPYS	DEG_SCF_FBW7_1	0.0556
p.S88F	DO48414	BLCA	ICGC	LTPPYS	DEG_SCF_FBW7_1	0.2222
p.S86N	DO223732	CESC	ICGC	LTPPYS	DEG_SCF_FBW7_1	0.1667
p.P83A	DO15631	HNSC	ICGC	LTPPYS	DEG_SCF_FBW7_1	0.0833
p.H107L	DO231132	LUSC	ICGC	LTPPYS	DEG_SCF_FBW7_1	0.0556
p.S104A	DO26701	LUSC	ICGC	LTPPYS	DEG_SCF_FBW7_1	0.1389
p.A102E	DO230449	UTCA	ICGC	LTPPYS	DEG_SCF_FBW7_1	0.1944
p.L92F	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPYS	DEG_SCF_FBW7_1	0.6981
p.L92F	ACH-000583	Lymphoma	CCLE	LTPPYS	DEG_SCF_FBW7_1	0.6981
p.L92F	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPYS	DEG_SCF_FBW7_1	0.6981
p.P95H	SIDM00986	Head and Neck Carcinoma	GDSC	LTPPYS	DEG_SCF_FBW7_1	0.6583
p.P95H	ACH-000548	Head and Neck Cancer	CCLE	LTPPYS	DEG_SCF_FBW7_1	0.6583
p.P95H	BHY	upper_aerodigestive_tract	COSMIC	LTPPYS	DEG_SCF_FBW7_1	0.6583
p.T93N	SIDM01612	Endometrial Carcinoma	GDSC	LTPPYS	DEG_SCF_FBW7_1	0.8166
p.T93N	ACH-000946	Endometrial/Uterine Cancer	CCLE	LTPPYS	DEG_SCF_FBW7_1	0.8166
p.D83N	ACH-001852	Bile Duct Cancer	CCLE	LTPPYS	DEG_SCF_FBW7_1	0.0833
p.P84H	BHY	upper_aerodigestive_tract	COSMIC	LTPPYS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13118	Krueppel-like factor 10	DEG_SCF_FBW7_1	92:97	LTPPYS	FBXW7	0.9996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons