DegronMD

Uniprot ID: Q13118

Source protein: Krueppel-like factor 10

Source gene: KLF10

Class: DEG_SIAH_1

Location: 200:208

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9971

ASA_SCORE: 82.0111

COIL: 0.9233

CONS_SCORE: 0.4891

DSS_SCORE: 0.3681

HELIX: 0.0349

FCONS_SCORE: 1.0238

RIG_SCORE: 0.7468

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A195V	TCGA-EO-A22U	UCEC	TCGA	IPCAAVSPN	DEG_SIAH_1	0.1944
p.D210H	DO2216	BRCA	ICGC	IPCAAVSPN	DEG_SIAH_1	0.2778
p.C201Y	DO50898	LICA	ICGC	IPCAAVSPN	DEG_SIAH_1	0.7087
p.S214I	DO23320	LINC	ICGC	IPCAAVSPN	DEG_SIAH_1	0.1667
p.D208A	DO23398	LINC	ICGC	IPCAAVSPN	DEG_SIAH_1	0.7793
p.Y218H	DO45317	LUAD	ICGC	IPCAAVSPN	DEG_SIAH_1	0.0556
p.R197I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IPCAAVSPN	DEG_SIAH_1	0.25
p.R197I	ACH-002256	Leukemia	CCLE	IPCAAVSPN	DEG_SIAH_1	0.25
p.R197I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IPCAAVSPN	DEG_SIAH_1	0.25
p.E194K	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	IPCAAVSPN	DEG_SIAH_1	0.1667
p.E194K	ACH-000886	Lung Cancer	CCLE	IPCAAVSPN	DEG_SIAH_1	0.1667
p.E194K	NCI-H2009	lung	COSMIC	IPCAAVSPN	DEG_SIAH_1	0.1667
p.A203V	SIDM00954	Breast Carcinoma	GDSC	IPCAAVSPN	DEG_SIAH_1	0.6936
p.A203V	ACH-001820	Breast Cancer	CCLE	IPCAAVSPN	DEG_SIAH_1	0.6936
p.A203V	COLO-824	breast	COSMIC	IPCAAVSPN	DEG_SIAH_1	0.6936
p.N199T	ACH-000973	Bladder Cancer	CCLE	IPCAAVSPN	DEG_SIAH_1	0.3056
p.V217M	ACH-001767	Non-Cancerous	CCLE	IPCAAVSPN	DEG_SIAH_1	0.0833
p.A213T	HEC-1	endometrium	COSMIC	IPCAAVSPN	DEG_SIAH_1	0.1944
p.A192V	COLO-824	breast	COSMIC	IPCAAVSPN	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13118	Krueppel-like factor 10	DEG_SIAH_1	200:208	IPCAAVSPN	SIAH1,SIAH2,SIAH3	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons