DegronMD - Q9NP81(SARS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P136L	TCGA-37-4130	LUSC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1111
p.P136L	DO26490	LUSC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1111
p.P136S	TCGA-37-4130	LUSC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1111
p.P136S	DO26490	LUSC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1111
p.A138D	TCGA-A5-A0G1	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.0556
p.A138D	DO42472	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.0556
p.R133W	TCGA-AX-A0J1	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1944
p.R133W	DO41199	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1944
p.R133W	SIDM01588	Endometrial Carcinoma	GDSC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1944
p.L134P	TCGA-AX-A1CE	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation blocking ubiquitination signal	0.6111
p.L134P	DO42280	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation blocking ubiquitination signal	0.6111
p.R133Q	TCGA-B5-A11H	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1944
p.R133Q	DO42825	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1944
p.V132E	TCGA-B9-4116	KIRP	TCGA	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.2222
p.V132E	DO20849	KIRP	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.2222
p.E115K	TCGA-DG-A2KK	CESC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1111
p.E115K	DO51595	CESC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1111
p.Q124H	TCGA-EE-A2GN	SKCM	TCGA	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation altering degron motif	0.647
p.P129S	DO7962	COAD	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.3056
p.R118W	DO230347	COCA	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1944
p.R118W	SIDM00971	Breast Carcinoma	GDSC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1944
p.R118W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.1944
p.P129T	DO229036	LICA	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.3056
p.C134F	DO22959	LIHC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation blocking ubiquitination signal	0.6111
p.G113R	DO50287	SKCM	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.0556
p.R126M	DO38129	SKCM	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation altering degron motif	0.8632
p.L138M	DO219773	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.0556
p.V125M	MDA-MB-468	breast	COSMIC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation altering degron motif	0.7208
p.T122I	GP5d	large intestine	COSMIC	NQDSGE	DEG_Kelch_Keap1_1	123:128	Mutation rewiring degron network	0.3056

Kaplan plot for SARS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SARS2

UniProt ID: Q9NP81

Entrez ID: 54938

Protein name: Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SARS2 in