DegronMD

Uniprot ID: Q9NP81

Source protein: Serine--tRNA ligase, mitochondrial

Source gene: SARS2

Class: DEG_Kelch_Keap1_1

Location: 123:128

E3 ligase: KEAP1

DEGRON score: 0.6887

ASA_SCORE: 93.9167

COIL: 0.808

CONS_SCORE: 0.2922

DSS_SCORE: 0.4738

HELIX: 0.1757

FCONS_SCORE: 0.9622

RIG_SCORE: 0.6786

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P136L	TCGA-37-4130	LUSC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.P136L	DO26490	LUSC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.P136S	TCGA-37-4130	LUSC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.P136S	DO26490	LUSC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.A138D	TCGA-A5-A0G1	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.0556
p.A138D	DO42472	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.0556
p.R133W	TCGA-AX-A0J1	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R133W	DO41199	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R133W	SIDM01588	Endometrial Carcinoma	GDSC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.L134P	TCGA-AX-A1CE	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.6111
p.L134P	DO42280	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.6111
p.R133Q	TCGA-B5-A11H	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R133Q	DO42825	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.V132E	TCGA-B9-4116	KIRP	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.2222
p.V132E	DO20849	KIRP	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.2222
p.E115K	TCGA-DG-A2KK	CESC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.E115K	DO51595	CESC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.Q124H	TCGA-EE-A2GN	SKCM	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.647
p.P129S	DO7962	COAD	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.3056
p.R118W	DO230347	COCA	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R118W	SIDM00971	Breast Carcinoma	GDSC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R118W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.P129T	DO229036	LICA	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.3056
p.C134F	DO22959	LIHC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.6111
p.G113R	DO50287	SKCM	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.0556
p.R126M	DO38129	SKCM	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.8632
p.L138M	DO219773	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.0556
p.V125M	MDA-MB-468	breast	COSMIC	NQDSGE	DEG_Kelch_Keap1_1	0.7208
p.T122I	GP5d	large_intestine	COSMIC	NQDSGE	DEG_Kelch_Keap1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NQDSGE

Degron related mutations and impact score

Drug responses associated with SARS2 mutations

All proteins holding degron of NQDSGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NP81	Serine--tRNA ligase, mitochondrial	DEG_Kelch_Keap1_1	123:128	NQDSGE	KEAP1	0.6887	More...