DegronMD

Uniprot ID: Q9NP81

Source protein: Serine--tRNA ligase, mitochondrial

Source gene: SARS2

Class: DEG_Kelch_Keap1_1

Location: 123:128

E3 ligase: KEAP1

DEGRON score: 0.6887

ASA_SCORE: 93.9167

COIL: 0.808

CONS_SCORE: 0.2922

DSS_SCORE: 0.4738

HELIX: 0.1757

FCONS_SCORE: 0.9622

RIG_SCORE: 0.6786

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R126M	DO38129	SKCM	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.8632
p.V125M	MDA-MB-468	breast	COSMIC	NQDSGE	DEG_Kelch_Keap1_1	0.7208
p.Q124H	TCGA-EE-A2GN	SKCM	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.647
p.L134P	TCGA-AX-A1CE	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.6111
p.L134P	DO42280	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.6111
p.C134F	DO22959	LIHC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.6111
p.P129S	DO7962	COAD	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.3056
p.P129T	DO229036	LICA	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.3056
p.T122I	GP5d	large_intestine	COSMIC	NQDSGE	DEG_Kelch_Keap1_1	0.3056
p.V132E	TCGA-B9-4116	KIRP	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.2222
p.V132E	DO20849	KIRP	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.2222
p.R133W	TCGA-AX-A0J1	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R133W	DO41199	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R133W	SIDM01588	Endometrial Carcinoma	GDSC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R133Q	TCGA-B5-A11H	UCEC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R133Q	DO42825	UCEC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R118W	DO230347	COCA	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R118W	SIDM00971	Breast Carcinoma	GDSC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.R118W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	NQDSGE	DEG_Kelch_Keap1_1	0.1944
p.P136L	TCGA-37-4130	LUSC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.P136L	DO26490	LUSC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.P136S	TCGA-37-4130	LUSC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.P136S	DO26490	LUSC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.E115K	TCGA-DG-A2KK	CESC	TCGA	NQDSGE	DEG_Kelch_Keap1_1	0.1111
p.E115K	DO51595	CESC	ICGC	NQDSGE	DEG_Kelch_Keap1_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NP81	Serine--tRNA ligase, mitochondrial	DEG_Kelch_Keap1_1	123:128	NQDSGE	KEAP1	0.6887	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons