DegronMD - Q9NP99(TREM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P155S	TCGA-AO-A03P	BRCA	TCGA	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6752
p.P155S	DO5633	BRCA	ICGC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6752
p.P155S	DO222837	MELA	ICGC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6752
p.K160E	TCGA-AX-A0J0	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.K160E	DO41133	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.E145D	TCGA-BS-A0UF	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0556
p.E145D	DO41488	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0556
p.K160N	TCGA-EE-A183	SKCM	TCGA	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.K160N	DO37715	SKCM	ICGC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.Y166F	DO228278	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1389
p.T148I	DO222837	MELA	ICGC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1389
p.T158S	SIDM00722	Mesothelioma	GDSC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6005
p.T158S	ACH-000092	Lung Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6005
p.T158S	NCI-H2452	pleura	COSMIC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6005
p.P169A	SIDM00002	Neuroblastoma	GDSC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0556
p.P169A	ACH-002340	Neuroblastoma	CCLE	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0556
p.P169A	NBsusSR	autonomic ganglia	COSMIC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0556
p.T159S	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6005
p.T159S	ACH-000311	Lung Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6005
p.T159S	NCI-H2122	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6005
p.P164T	SIDM00049	Colorectal Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1944
p.P164T	ACH-002233	Colon/Colorectal Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1944
p.P164T	DIFI	large intestine	COSMIC	PPTTT	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1944

Kaplan plot for TREM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TREM1

UniProt ID: Q9NP99

Entrez ID: 54210

Protein name: Triggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TREM1 in