PARD6A
UniProt ID: Q9NPB6
Entrez ID: 50855
Protein name: Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 ...
FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}.
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GO - Biological processes (BP):
cell-cell junction maintenance [GO:0045217]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; negative regulation of protein phosphorylation [GO:0...
cell-cell junction maintenance [GO:0045217]; cell division [GO:0051301]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of protein secretion [GO:0050714]; regulation of cellular localization [GO:0060341]; viral process [GO:0016032]
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GO - Molecular function (MF):
GTP-dependent protein binding [GO:0030742]; protein kinase C binding [GO:0005080]; small GTPase binding [GO:0031267]; transcription factor binding [GO:0008134]...
GTP-dependent protein binding [GO:0030742]; protein kinase C binding [GO:0005080]; small GTPase binding [GO:0031267]; transcription factor binding [GO:0008134]
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GO - Cellular component (CC):
apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; tight j...
apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; tight junction [GO:0070160]
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PARD6A
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Kaplan plot for PARD6A in
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*NOTE: the Kaplan plots were collected from OncoLnc