DegronMD

Uniprot ID: Q9NPB6

Source protein: Partitioning defective 6 homolog alpha

Source gene: PARD6A

Class: DEG_APCC_DBOX_1

Location: 316:324

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9498

ASA_SCORE: 76.9778

COIL: 0.861

CONS_SCORE: 0.5534

DSS_SCORE: 0.6752

HELIX: 0.0921

FCONS_SCORE: 1.0203

RIG_SCORE: 0.6506

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P309T	TCGA-FS-A1ZB	SKCM	TCGA	TRSSLPSLD	DEG_APCC_DBOX_1	0.1389
p.G334V	TCGA-FS-A1ZJ	SKCM	TCGA	TRSSLPSLD	DEG_APCC_DBOX_1	0.0556
p.R308L	DO229018	LICA	ICGC	TRSSLPSLD	DEG_APCC_DBOX_1	0.1111
p.R308L	DO47442	SKCM	ICGC	TRSSLPSLD	DEG_APCC_DBOX_1	0.1111
p.R306H	DO43186	UCEC	ICGC	TRSSLPSLD	DEG_APCC_DBOX_1	0.0556
p.R317H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	TRSSLPSLD	DEG_APCC_DBOX_1	0.8244
p.R317H	ACH-000918	Leukemia	CCLE	TRSSLPSLD	DEG_APCC_DBOX_1	0.8244
p.R317H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	TRSSLPSLD	DEG_APCC_DBOX_1	0.8244
p.W333R	SIDM01619	Endometrial Carcinoma	GDSC	TRSSLPSLD	DEG_APCC_DBOX_1	0.0833
p.W333R	ACH-000984	Endometrial/Uterine Cancer	CCLE	TRSSLPSLD	DEG_APCC_DBOX_1	0.0833
p.R316H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	TRSSLPSLD	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPB6	Partitioning defective 6 homolog alpha	DEG_APCC_DBOX_1	316:324	TRSSLPSLD	APC,CDC20,FZR1	0.9498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons