SIX2
UniProt ID: Q9NPC8
Entrez ID: 10736
Protein name: Homeobox protein SIX2 (Sine oculis homeobox homolog 2)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating fro...
FUNCTION: Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration. {ECO:0000250|UniProtKB:Q62232, ECO:0000269|PubMed:22995329}.
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GO - Biological processes (BP):
anatomical structure morphogenesis [GO:0009653]; anterior/posterior axis specification [GO:0009948]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; condensed mesenchymal cell proliferation [GO:0072137]; embryonic cranial skeleton mo...
anatomical structure morphogenesis [GO:0009653]; anterior/posterior axis specification [GO:0009948]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; condensed mesenchymal cell proliferation [GO:0072137]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; kidney development [GO:0001822]; mesenchymal cell differentiation involved in kidney development [GO:0072161]; mesenchymal stem cell maintenance involved in nephron morphogenesis [GO:0072038]; mesenchymal stem cell proliferation [GO:0097168]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesodermal cell fate specification [GO:0007501]; middle ear morphogenesis [GO:0042474]; negative regulation of cell differentiation [GO:0045596]; nephron development [GO:0072006]; nephron morphogenesis [GO:0072028]; positive regulation of chondrocyte proliferation [GO:1902732]; protein import into nucleus [GO:0006606]; regulation of branching involved in ureteric bud morphogenesis [GO:0090189]; regulation of chondrocyte differentiation [GO:0032330]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]
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GO - Molecular function (MF):
DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-re...
DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]
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GO - Cellular component (CC):
chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]...
chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]
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SIX2
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Kaplan plot for SIX2 in
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*NOTE: the Kaplan plots were collected from OncoLnc