DegronMD

Uniprot ID: Q9NPC8

Source protein: Homeobox protein SIX2

Source gene: SIX2

Class: DEG_SCF_FBW7_1

Location: 218:225

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 85.9

COIL: 0.9583

CONS_SCORE: 0.2818

DSS_SCORE: 0.7895

HELIX: 0.0283

FCONS_SCORE: 0.9819

RIG_SCORE: 0.4974

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P229A	TCGA-62-8399	LUAD	TCGA	PSGTPDHS	DEG_SCF_FBW7_1	0.2222
p.P229A	DO24606	LUAD	ICGC	PSGTPDHS	DEG_SCF_FBW7_1	0.2222
p.T217I	TCGA-AA-A010	COAD	TCGA	PSGTPDHS	DEG_SCF_FBW7_1	0.3056
p.S219L	TCGA-AX-A06F	UCEC	TCGA	PSGTPDHS	DEG_SCF_FBW7_1	0.6556
p.S219L	DO41752	UCEC	ICGC	PSGTPDHS	DEG_SCF_FBW7_1	0.6556
p.E213D	TCGA-B5-A3FC	UCEC	TCGA	PSGTPDHS	DEG_SCF_FBW7_1	0.1944
p.E213D	DO41871	UCEC	ICGC	PSGTPDHS	DEG_SCF_FBW7_1	0.1944
p.G220W	TCGA-BF-A1PU	SKCM	TCGA	PSGTPDHS	DEG_SCF_FBW7_1	0.6714
p.G220W	DO50278	SKCM	ICGC	PSGTPDHS	DEG_SCF_FBW7_1	0.6714
p.S226T	TCGA-DD-A1EJ	LIHC	TCGA	PSGTPDHS	DEG_SCF_FBW7_1	0.3056
p.S226T	DO22994	LIHC	ICGC	PSGTPDHS	DEG_SCF_FBW7_1	0.3056
p.S225L	TCGA-EE-A2MR	SKCM	TCGA	PSGTPDHS	DEG_SCF_FBW7_1	0.7667
p.S225L	DO37819	SKCM	ICGC	PSGTPDHS	DEG_SCF_FBW7_1	0.7667
p.E213K	DO227947	BRCA	ICGC	PSGTPDHS	DEG_SCF_FBW7_1	0.1944
p.A230T	DO222755	COCA	ICGC	PSGTPDHS	DEG_SCF_FBW7_1	0.1944
p.A230T	SIDM01090	Colorectal Carcinoma	GDSC	PSGTPDHS	DEG_SCF_FBW7_1	0.1944
p.A230T	ACH-000943	Colon/Colorectal Cancer	CCLE	PSGTPDHS	DEG_SCF_FBW7_1	0.1944
p.A230T	RKO	large_intestine	COSMIC	PSGTPDHS	DEG_SCF_FBW7_1	0.1944
p.P235S	DO46368	OV	ICGC	PSGTPDHS	DEG_SCF_FBW7_1	0.0556
p.G220V	SIDM00258	Neuroblastoma	GDSC	PSGTPDHS	DEG_SCF_FBW7_1	0.6421
p.G220V	ACH-002279	Neuroblastoma	CCLE	PSGTPDHS	DEG_SCF_FBW7_1	0.6421
p.G220V	NB12	autonomic_ganglia	COSMIC	PSGTPDHS	DEG_SCF_FBW7_1	0.6421
p.S211G	ACH-001802	Liposarcoma	CCLE	PSGTPDHS	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPC8	Homeobox protein SIX2	DEG_SCF_FBW7_1	218:225	PSGTPDHS	FBXW7	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons