DegronMD - Q9NPH6(OBP2B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K150N	TCGA-D3-A1Q3	SKCM	TCGA	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation substituting flanking lysine	0.25
p.K150N	DO47509	SKCM	ICGC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation substituting flanking lysine	0.25
p.G164E	TCGA-DA-A3F8	SKCM	TCGA	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.3056
p.S153L	TCGA-EA-A410	CESC	TCGA	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation blocking phosphorylation signal	0.6667
p.S153L	DO49929	CESC	ICGC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation blocking phosphorylation signal	0.6667
p.E169K	TCGA-EE-A181	SKCM	TCGA	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1667
p.E169K	DO37444	SKCM	ICGC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1667
p.R149H	DO227988	COCA	ICGC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1111
p.P160S	DO234420	ESAD	ICGC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.6752
p.T159M	DO233888	GACA	ICGC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7423
p.R149C	DO51039	LAML	ICGC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1111
p.E155K	DO218861	SKCA	ICGC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.2778
p.T163A	SIDM00557	Neuroblastoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00584	Osteosarcoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00602	Gastric Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00193	Colorectal Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00264	Ewing's Sarcoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00457	Plasma Cell Myeloma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM01148	Plasma Cell Myeloma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00235	Kidney Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00587	Biliary Tract Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00549	B-Lymphoblastic Leukemia	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00986	Head and Neck Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00996	Thyroid Gland Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM00381	Cervical Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM01526	Mesothelioma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM01749	Osteosarcoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM01435	Hepatocellular Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139
p.T163A	SIDM01763	Rhabdomyosarcoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OBP2B

UniProt ID: Q9NPH6

Entrez ID: 29989

Protein name: Odorant-binding protein 2b (Odorant-binding protein IIb) (OBPIIb)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for OBP2B in