DegronMD

Uniprot ID: Q9NPH6

Source protein: Odorant-binding protein 2b

Source gene: OBP2B

Class: DEG_SCF_FBW7_1

Location: 157:163

E3 ligase: FBXW7

DEGRON score: 0.952

ASA_SCORE: 70.7571

COIL: 0.672

CONS_SCORE: 0.3985

DSS_SCORE: 0.4913

HELIX: 0.0576

FCONS_SCORE: 0.9308

RIG_SCORE: 0.7635

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K150N	TCGA-D3-A1Q3	SKCM	TCGA	IFTPLQT	DEG_SCF_FBW7_1	0.25
p.K150N	DO47509	SKCM	ICGC	IFTPLQT	DEG_SCF_FBW7_1	0.25
p.G164E	TCGA-DA-A3F8	SKCM	TCGA	IFTPLQT	DEG_SCF_FBW7_1	0.3056
p.S153L	TCGA-EA-A410	CESC	TCGA	IFTPLQT	DEG_SCF_FBW7_1	0.6667
p.S153L	DO49929	CESC	ICGC	IFTPLQT	DEG_SCF_FBW7_1	0.6667
p.E169K	TCGA-EE-A181	SKCM	TCGA	IFTPLQT	DEG_SCF_FBW7_1	0.1667
p.E169K	DO37444	SKCM	ICGC	IFTPLQT	DEG_SCF_FBW7_1	0.1667
p.R149H	DO227988	COCA	ICGC	IFTPLQT	DEG_SCF_FBW7_1	0.1111
p.P160S	DO234420	ESAD	ICGC	IFTPLQT	DEG_SCF_FBW7_1	0.6752
p.T159M	DO233888	GACA	ICGC	IFTPLQT	DEG_SCF_FBW7_1	0.7423
p.R149C	DO51039	LAML	ICGC	IFTPLQT	DEG_SCF_FBW7_1	0.1111
p.E155K	DO218861	SKCA	ICGC	IFTPLQT	DEG_SCF_FBW7_1	0.2778
p.T163A	SIDM00557	Neuroblastoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00584	Osteosarcoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00602	Gastric Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00193	Colorectal Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00264	Ewing's Sarcoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00457	Plasma Cell Myeloma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM01148	Plasma Cell Myeloma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00235	Kidney Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00587	Biliary Tract Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00549	B-Lymphoblastic Leukemia	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00986	Head and Neck Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00996	Thyroid Gland Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM00381	Cervical Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM01526	Mesothelioma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM01749	Osteosarcoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM01435	Hepatocellular Carcinoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139
p.T163A	SIDM01763	Rhabdomyosarcoma	GDSC	IFTPLQT	DEG_SCF_FBW7_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IFTPLQT

Degron related mutations and impact score

Drug responses associated with OBP2B mutations

All proteins holding degron of IFTPLQT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPH6	Odorant-binding protein 2b	DEG_SCF_FBW7_1	157:163	IFTPLQT	FBXW7	0.952	More...