DegronMD - Q9NQ66(PLCB1)

GO - Biological processes (BP): activation of meiosis involved in egg activation [GO:0060466]; cellular response to fluoride [GO:1902618]; cellular response to glyceraldehyde [GO:1905631]; cellular response to ionomycin [GO:1904637]; cellular response to vasopressin [GO:1904117]; cerebral cortex development [GO:0021987]; fat cell differentiation [GO:0045444]; G2/M transition of mitotic cell cycle [GO:0000086]; glutamate receptor signaling pathway [GO:0007215]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; inositol trisphosphate metabolic process [GO:0032957]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-1-mediated signaling pathway [GO:0070498]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of monocyte extravasation [GO:2000438]; negative regulation of transcription, DNA-templated [GO:0045892]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphatidylinositol metabolic process [GO:0046488]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of CD24 production [GO:2000560]; positive regulation of developmental growth [GO:0048639]; positive regulation of embryonic development [GO:0040019]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription, DNA-templated [GO:0045893]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of fertilization [GO:0080154]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; signal transduction [GO:0007165] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P787T	TCGA-17-Z010	LUAD	TCGA	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.2778
p.E779K	TCGA-4Z-AA7Y	BLCA	TCGA	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.0556
p.E779K	DO51867	BLCA	ICGC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.0556
p.K796E	TCGA-85-8288	LUSC	TCGA	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.2778
p.K796E	DO26963	LUSC	ICGC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.2778
p.D801H	TCGA-95-7948	LUAD	TCGA	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.1389
p.D801H	DO25133	LUAD	ICGC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.1389
p.L784V	DO48360	BLCA	ICGC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.1944
p.T785M	DO222765	COCA	ICGC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.2222
p.T785M	SIDM00685	Glioblastoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.2222
p.T785M	ACH-000819	Brain Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.2222
p.T785M	LN-18	central nervous system	COSMIC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.2222
p.P800S	DO229275	THCA	ICGC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.1667
p.K796R	SIDM00511	Small Cell Lung Carcinoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.2778
p.K796R	ACH-000257	Lung Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.2778
p.K796R	COR-L279	lung	COSMIC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.2778
p.V799A	SIDM00217	Colorectal Carcinoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.1944
p.V799A	ACH-000999	Colon/Colorectal Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.1944
p.V799A	SNU-1040	large intestine	COSMIC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.1944
p.R780G	SIDM00638	Cervical Carcinoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.0833
p.R780G	ACH-001360	Cervical Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.0833
p.R780G	MS751	cervix	COSMIC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.0833
p.I793T	SIDM00225	Melanoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation altering degron motif	0.5966
p.I793T	ACH-002143	Skin Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation altering degron motif	0.5966
p.I793T	IST-MEL1	skin	COSMIC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation altering degron motif	0.5966
p.A788V	SIDM01729	Endometrial Carcinoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.3056
p.A788V	ACH-000909	Endometrial/Uterine Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.3056
p.P800Q	ACH-000737	Lung Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.1667
p.P784A	EJM	haematopoietic and lymphoid tissue	COSMIC	VFVYIE	LIG_APCC_ABBA_1	789:794	Mutation rewiring degron network	0.1944

Kaplan plot for PLCB1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLCB1

UniProt ID: Q9NQ66

Entrez ID: 23236

Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PLCB1 in