DegronMD

Uniprot ID: Q9NQ66

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Source gene: PLCB1

Class: LIG_APCC_ABBA_1

Location: 789:794

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7193

ASA_SCORE: 20.2833

COIL: 0.021

CONS_SCORE: 0.5235

DSS_SCORE: 0.0397

HELIX: 0.0027

FCONS_SCORE: 1.3794

RIG_SCORE: 0.9736

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P787T	TCGA-17-Z010	LUAD	TCGA	VFVYIE	LIG_APCC_ABBA_1	0.2778
p.E779K	TCGA-4Z-AA7Y	BLCA	TCGA	VFVYIE	LIG_APCC_ABBA_1	0.0556
p.E779K	DO51867	BLCA	ICGC	VFVYIE	LIG_APCC_ABBA_1	0.0556
p.K796E	TCGA-85-8288	LUSC	TCGA	VFVYIE	LIG_APCC_ABBA_1	0.2778
p.K796E	DO26963	LUSC	ICGC	VFVYIE	LIG_APCC_ABBA_1	0.2778
p.D801H	TCGA-95-7948	LUAD	TCGA	VFVYIE	LIG_APCC_ABBA_1	0.1389
p.D801H	DO25133	LUAD	ICGC	VFVYIE	LIG_APCC_ABBA_1	0.1389
p.L784V	DO48360	BLCA	ICGC	VFVYIE	LIG_APCC_ABBA_1	0.1944
p.T785M	DO222765	COCA	ICGC	VFVYIE	LIG_APCC_ABBA_1	0.2222
p.T785M	SIDM00685	Glioblastoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	0.2222
p.T785M	ACH-000819	Brain Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	0.2222
p.T785M	LN-18	central_nervous_system	COSMIC	VFVYIE	LIG_APCC_ABBA_1	0.2222
p.P800S	DO229275	THCA	ICGC	VFVYIE	LIG_APCC_ABBA_1	0.1667
p.K796R	SIDM00511	Small Cell Lung Carcinoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	0.2778
p.K796R	ACH-000257	Lung Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	0.2778
p.K796R	COR-L279	lung	COSMIC	VFVYIE	LIG_APCC_ABBA_1	0.2778
p.V799A	SIDM00217	Colorectal Carcinoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	0.1944
p.V799A	ACH-000999	Colon/Colorectal Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	0.1944
p.V799A	SNU-1040	large_intestine	COSMIC	VFVYIE	LIG_APCC_ABBA_1	0.1944
p.R780G	SIDM00638	Cervical Carcinoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	0.0833
p.R780G	ACH-001360	Cervical Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	0.0833
p.R780G	MS751	cervix	COSMIC	VFVYIE	LIG_APCC_ABBA_1	0.0833
p.I793T	SIDM00225	Melanoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	0.5966
p.I793T	ACH-002143	Skin Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	0.5966
p.I793T	IST-MEL1	skin	COSMIC	VFVYIE	LIG_APCC_ABBA_1	0.5966
p.A788V	SIDM01729	Endometrial Carcinoma	GDSC	VFVYIE	LIG_APCC_ABBA_1	0.3056
p.A788V	ACH-000909	Endometrial/Uterine Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	0.3056
p.P800Q	ACH-000737	Lung Cancer	CCLE	VFVYIE	LIG_APCC_ABBA_1	0.1667
p.P784A	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	VFVYIE	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VFVYIE

Degron related mutations and impact score

Drug responses associated with PLCB1 mutations

All proteins holding degron of VFVYIE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	LIG_APCC_ABBA_1	789:794	VFVYIE	APC,CDC20,FZR1	0.7193	More...