DegronMD - Q9NQ89(C12orf4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R405S	TCGA-96-7544	LUSC	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.7427
p.R405S	DO26425	LUSC	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.7427
p.R405M	TCGA-96-7544	LUSC	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.8632
p.R405M	DO26425	LUSC	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.8632
p.N409T	TCGA-AP-A059	UCEC	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.5944
p.N409T	DO41361	UCEC	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.5944
p.L411V	TCGA-CA-6718	COAD	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.5654
p.L411V	DO7801	COAD	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.5654
p.R419L	TCGA-D3-A2J6	SKCM	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1389
p.R419L	DO37901	SKCM	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1389
p.G413V	TCGA-D3-A3CE	SKCM	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.3056
p.G413V	DO37405	SKCM	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.3056
p.P412H	TCGA-D3-A3CE	SKCM	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.6583
p.P412H	DO37405	SKCM	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.6583
p.E414K	TCGA-F5-6814	READ	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.2778
p.E414K	DO36556	READ	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.2778
p.R419Q	TCGA-IB-7651	PAAD	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1389
p.R419Q	DO46657	PAAD	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1389
p.E404Q	TCGA-K4-AAQO	BLCA	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.5633
p.E404Q	DO219030	BLCA	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.5633
p.E404K	DO14566	HNSC	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.591
p.R419W	SIDM01612	Endometrial Carcinoma	GDSC	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1389
p.R419W	ACH-000946	Endometrial/Uterine Cancer	CCLE	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1389
p.D398G	ACH-000179	Lung Cancer	CCLE	ERNYLNVLP	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1667

Kaplan plot for C12orf4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C12orf4

UniProt ID: Q9NQ89

Entrez ID: 57102

Protein name: Protein C12orf4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C12orf4 in