DegronMD

Uniprot ID: Q9NQ89

Source protein: Protein C12orf4

Source gene: C12orf4

Class: DEG_APCC_DBOX_1

Location: 404:412

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9859

ASA_SCORE: 79.8222

COIL: 0.7514

CONS_SCORE: 0.3352

DSS_SCORE: 0.3358

HELIX: 0.1277

FCONS_SCORE: 0.6077

RIG_SCORE: 0.8112

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R405M	TCGA-96-7544	LUSC	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	0.8632
p.R405M	DO26425	LUSC	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.8632
p.R405S	TCGA-96-7544	LUSC	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	0.7427
p.R405S	DO26425	LUSC	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.7427
p.P412H	TCGA-D3-A3CE	SKCM	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	0.6583
p.P412H	DO37405	SKCM	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.6583
p.N409T	TCGA-AP-A059	UCEC	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	0.5944
p.N409T	DO41361	UCEC	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.5944
p.E404K	DO14566	HNSC	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.591
p.L411V	TCGA-CA-6718	COAD	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	0.5654
p.L411V	DO7801	COAD	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.5654
p.E404Q	TCGA-K4-AAQO	BLCA	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	0.5633
p.E404Q	DO219030	BLCA	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.5633
p.G413V	TCGA-D3-A3CE	SKCM	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	0.3056
p.G413V	DO37405	SKCM	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.3056
p.E414K	TCGA-F5-6814	READ	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	0.2778
p.E414K	DO36556	READ	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.2778
p.D398G	ACH-000179	Lung Cancer	CCLE	ERNYLNVLP	DEG_APCC_DBOX_1	0.1667
p.R419L	TCGA-D3-A2J6	SKCM	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	0.1389
p.R419L	DO37901	SKCM	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.1389
p.R419Q	TCGA-IB-7651	PAAD	TCGA	ERNYLNVLP	DEG_APCC_DBOX_1	0.1389
p.R419Q	DO46657	PAAD	ICGC	ERNYLNVLP	DEG_APCC_DBOX_1	0.1389
p.R419W	SIDM01612	Endometrial Carcinoma	GDSC	ERNYLNVLP	DEG_APCC_DBOX_1	0.1389
p.R419W	ACH-000946	Endometrial/Uterine Cancer	CCLE	ERNYLNVLP	DEG_APCC_DBOX_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ89	Protein C12orf4	DEG_APCC_DBOX_1	404:412	ERNYLNVLP	APC,CDC20,FZR1	0.9859	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons