DegronMD - Q9NQ92(COPRS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F112Y	TCGA-AA-3977	COAD	TCGA	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation altering degron motif	0.7528
p.F112Y	DO8730	COAD	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation altering degron motif	0.7528
p.D110Y	TCGA-D6-A6EQ	HNSC	TCGA	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation rewiring degron network	0.2778
p.D110Y	DO52085	HNSC	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation rewiring degron network	0.2778
p.E114D	TCGA-DF-A2KU	UCEC	TCGA	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation altering degron motif	0.5647
p.E114D	DO223286	UCEC	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation altering degron motif	0.5647
p.F112V	TCGA-FA-A4BB	DLBC	TCGA	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation altering degron motif	0.7068
p.F112V	DO219885	DLBC	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation altering degron motif	0.7068
p.D115E	DO229027	LICA	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation altering degron motif	0.5647
p.D110N	DO52670	MALY	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation rewiring degron network	0.2778
p.P127S	DO220891	MELA	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation rewiring degron network	0.1389
p.G125R	SIDM00516	Melanoma	GDSC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation rewiring degron network	0.1944
p.G125R	ACH-002166	Skin Cancer	CCLE	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation rewiring degron network	0.1944
p.G125R	MZ7-mel	skin	COSMIC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation rewiring degron network	0.1944
p.L111F	ACH-001367	Neuroblastoma	CCLE	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation rewiring degron network	0.3056
p.L129F	CAL-85-1	breast	COSMIC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation rewiring degron network	0.0833
p.G113R	MZ7-mel	skin	COSMIC	FNEDWDSEL	DEG_MDM2_SWIB_1	112:120	Mutation altering degron motif	0.7568

Kaplan plot for COPRS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COPRS

UniProt ID: Q9NQ92

Entrez ID: 55352

Protein name: Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COPRS in