DegronMD

Uniprot ID: Q9NQ92

Source protein: Coordinator of PRMT5 and differentiation stimulator

Source gene: COPRS

Class: DEG_MDM2_SWIB_1

Location: 112:120

E3 ligase: MDM2

DEGRON score: 0.9128

ASA_SCORE: 72.0222

COIL: 0.4576

CONS_SCORE: 0.9298

DSS_SCORE: 0.6776

HELIX: 0.4823

FCONS_SCORE: 1.0623

RIG_SCORE: 0.7592

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F112Y	TCGA-AA-3977	COAD	TCGA	FNEDWDSEL	DEG_MDM2_SWIB_1	0.7528
p.F112Y	DO8730	COAD	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.7528
p.D110Y	TCGA-D6-A6EQ	HNSC	TCGA	FNEDWDSEL	DEG_MDM2_SWIB_1	0.2778
p.D110Y	DO52085	HNSC	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.2778
p.E114D	TCGA-DF-A2KU	UCEC	TCGA	FNEDWDSEL	DEG_MDM2_SWIB_1	0.5647
p.E114D	DO223286	UCEC	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.5647
p.F112V	TCGA-FA-A4BB	DLBC	TCGA	FNEDWDSEL	DEG_MDM2_SWIB_1	0.7068
p.F112V	DO219885	DLBC	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.7068
p.D115E	DO229027	LICA	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.5647
p.D110N	DO52670	MALY	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.2778
p.P127S	DO220891	MELA	ICGC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.1389
p.G125R	SIDM00516	Melanoma	GDSC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.1944
p.G125R	ACH-002166	Skin Cancer	CCLE	FNEDWDSEL	DEG_MDM2_SWIB_1	0.1944
p.G125R	MZ7-mel	skin	COSMIC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.1944
p.L111F	ACH-001367	Neuroblastoma	CCLE	FNEDWDSEL	DEG_MDM2_SWIB_1	0.3056
p.L129F	CAL-85-1	breast	COSMIC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.0833
p.G113R	MZ7-mel	skin	COSMIC	FNEDWDSEL	DEG_MDM2_SWIB_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ92	Coordinator of PRMT5 and differentiation stimulator	DEG_MDM2_SWIB_1	112:120	FNEDWDSEL	MDM2	0.9128	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons