DegronMD - Q9NQX7(ITM2C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E41K	TCGA-DA-A960	SKCM	TCGA	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation altering degron motif	0.7022
p.K50N	TCGA-FD-A3SJ	BLCA	TCGA	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation substituting flanking lysine	0.1944
p.K50N	DO681	BLCA	ICGC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation substituting flanking lysine	0.1944
p.A24V	DO225337	BRCA	ICGC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation rewiring degron network	0.0556
p.R48C	DO1285	BRCA	ICGC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation rewiring degron network	0.1389
p.A29T	DO222501	COCA	ICGC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation rewiring degron network	0.1944
p.A42S	DO30570	OV	ICGC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation rewiring degron network	0.3056
p.R47W	DO37823	SKCM	ICGC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation rewiring degron network	0.1667
p.R40G	DO229242	THCA	ICGC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation altering degron motif	0.6457
p.P28L	SIDM00945	Colorectal Carcinoma	GDSC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation rewiring degron network	0.1667
p.A39P	SIDM00849	Kidney Carcinoma	GDSC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation altering degron motif	0.6392
p.A39P	SIDM00721	Small Cell Lung Carcinoma	GDSC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation altering degron motif	0.6392
p.E33K	SIDM00794	Other Solid Cancers	GDSC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation rewiring degron network	0.3056
p.R51M	ACH-000088	Non-Cancerous	CCLE	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation rewiring degron network	0.0556
p.N30S	ACH-000978	Endometrial/Uterine Cancer	CCLE	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation blocking phosphorylation signal	0.6667
p.N30S	EN	endometrium	COSMIC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation blocking phosphorylation signal	0.6667
p.N45S	EN	endometrium	COSMIC	ILLTPARE	DEG_SCF_FBW7_2	34:41	Mutation rewiring degron network	0.2222

Kaplan plot for ITM2C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITM2C

UniProt ID: Q9NQX7

Entrez ID: 81618

Protein name: Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITM2C in