DegronMD

Uniprot ID: Q9NQX7

Source protein: Integral membrane protein 2C

Source gene: ITM2C

Class: DEG_SCF_FBW7_2

Location: 34:41

E3 ligase: FBXW7

DEGRON score: 0.5831

ASA_SCORE: 80.1625

COIL: 0.6878

CONS_SCORE: 0.296

DSS_SCORE: 0.6708

HELIX: 0.1726

FCONS_SCORE: 1.0188

RIG_SCORE: 0.7245

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E41K	TCGA-DA-A960	SKCM	TCGA	ILLTPARE	DEG_SCF_FBW7_2	0.7022
p.K50N	TCGA-FD-A3SJ	BLCA	TCGA	ILLTPARE	DEG_SCF_FBW7_2	0.1944
p.K50N	DO681	BLCA	ICGC	ILLTPARE	DEG_SCF_FBW7_2	0.1944
p.A24V	DO225337	BRCA	ICGC	ILLTPARE	DEG_SCF_FBW7_2	0.0556
p.R48C	DO1285	BRCA	ICGC	ILLTPARE	DEG_SCF_FBW7_2	0.1389
p.A29T	DO222501	COCA	ICGC	ILLTPARE	DEG_SCF_FBW7_2	0.1944
p.A42S	DO30570	OV	ICGC	ILLTPARE	DEG_SCF_FBW7_2	0.3056
p.R47W	DO37823	SKCM	ICGC	ILLTPARE	DEG_SCF_FBW7_2	0.1667
p.R40G	DO229242	THCA	ICGC	ILLTPARE	DEG_SCF_FBW7_2	0.6457
p.P28L	SIDM00945	Colorectal Carcinoma	GDSC	ILLTPARE	DEG_SCF_FBW7_2	0.1667
p.A39P	SIDM00849	Kidney Carcinoma	GDSC	ILLTPARE	DEG_SCF_FBW7_2	0.6392
p.A39P	SIDM00721	Small Cell Lung Carcinoma	GDSC	ILLTPARE	DEG_SCF_FBW7_2	0.6392
p.E33K	SIDM00794	Other Solid Cancers	GDSC	ILLTPARE	DEG_SCF_FBW7_2	0.3056
p.R51M	ACH-000088	Non-Cancerous	CCLE	ILLTPARE	DEG_SCF_FBW7_2	0.0556
p.N30S	ACH-000978	Endometrial/Uterine Cancer	CCLE	ILLTPARE	DEG_SCF_FBW7_2	0.6667
p.N30S	EN	endometrium	COSMIC	ILLTPARE	DEG_SCF_FBW7_2	0.6667
p.N45S	EN	endometrium	COSMIC	ILLTPARE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQX7	Integral membrane protein 2C	DEG_SCF_FBW7_2	34:41	ILLTPARE	FBXW7	0.5831	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons