DegronMD - Q9NR30(DDX21)

FUNCTION: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R440H	TCGA-AX-A0J1	UCEC	TCGA	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation altering degron motif	0.8244
p.R440H	DO41199	UCEC	ICGC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation altering degron motif	0.8244
p.R440C	TCGA-BR-8078	STAD	TCGA	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation altering degron motif	0.8301
p.R440C	DO38288	STAD	ICGC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation altering degron motif	0.8301
p.Q438E	TCGA-XF-AAN0	BLCA	TCGA	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.2778
p.Q438E	DO51941	BLCA	ICGC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.2778
p.A451S	DO229028	LICA	ICGC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.1944
p.Y434H	SIDM00284	Melanoma	GDSC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.1667
p.Y434H	SIDM01059	Melanoma	GDSC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.1667
p.I431V	SIDM01045	Endometrial Carcinoma	GDSC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.0833
p.I431V	ACH-000978	Endometrial/Uterine Cancer	CCLE	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.0833
p.I431V	EN	endometrium	COSMIC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.0833
p.E446Q	SIDM00898	Breast Carcinoma	GDSC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation altering degron motif	0.6744
p.E446Q	ACH-000248	Breast Cancer	CCLE	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation altering degron motif	0.6744
p.E446Q	AU565	breast	COSMIC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation altering degron motif	0.6744
p.E453K	SIDM00150	Colorectal Carcinoma	GDSC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.1389
p.E453K	ACH-000969	Colon/Colorectal Cancer	CCLE	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.1389
p.E453K	KM12	large intestine	COSMIC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	440:446	Mutation rewiring degron network	0.1389

Kaplan plot for DDX21 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDX21

UniProt ID: Q9NR30

Entrez ID: 9188

Protein name: Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DDX21 in