DegronMD

Uniprot ID: Q9NR30

Source protein: Nucleolar RNA helicase 2

Source gene: DDX21

Class: LIG_APCC_ABBAyCdc20_2

Location: 440:446

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5208

ASA_SCORE: 21.2

COIL: 0.2809

CONS_SCORE: 0.6072

DSS_SCORE: 0.2596

HELIX: 0.0124

FCONS_SCORE: 1.4436

RIG_SCORE: 0.8872

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R440H	TCGA-AX-A0J1	UCEC	TCGA	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R440H	DO41199	UCEC	ICGC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R440C	TCGA-BR-8078	STAD	TCGA	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R440C	DO38288	STAD	ICGC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.8301
p.Q438E	TCGA-XF-AAN0	BLCA	TCGA	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q438E	DO51941	BLCA	ICGC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A451S	DO229028	LICA	ICGC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.1944
p.Y434H	SIDM00284	Melanoma	GDSC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.1667
p.Y434H	SIDM01059	Melanoma	GDSC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.1667
p.I431V	SIDM01045	Endometrial Carcinoma	GDSC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.0833
p.I431V	ACH-000978	Endometrial/Uterine Cancer	CCLE	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.0833
p.I431V	EN	endometrium	COSMIC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E446Q	SIDM00898	Breast Carcinoma	GDSC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.6744
p.E446Q	ACH-000248	Breast Cancer	CCLE	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.6744
p.E446Q	AU565	breast	COSMIC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.6744
p.E453K	SIDM00150	Colorectal Carcinoma	GDSC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E453K	ACH-000969	Colon/Colorectal Cancer	CCLE	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E453K	KM12	large_intestine	COSMIC	RTIIFCE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR30	Nucleolar RNA helicase 2	LIG_APCC_ABBAyCdc20_2	440:446	RTIIFCE	APC,CDC20,FZR1	0.5208	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons