DegronMD - Q9NR81(ARHGEF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D358E	TCGA-24-2030	OV	TCGA	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.2778
p.S363R	TCGA-AX-A1CE	UCEC	TCGA	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1389
p.D362N	TCGA-EO-A22R	UCEC	TCGA	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1667
p.D362N	SIDM00590	Oral Cavity Carcinoma	GDSC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1667
p.D362N	HSC-2	upper aerodigestive tract	COSMIC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1667
p.L349F	TCGA-FG-A6IZ	LGG	TCGA	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.2778
p.R343S	TCGA-FS-A1ZG	SKCM	TCGA	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1111
p.R345W	DO8730	COAD	ICGC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1667
p.R345W	DO233908	GACA	ICGC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1667
p.V347L	DO23645	LUAD	ICGC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.2222
p.L341P	DO229229	THCA	ICGC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.0556
p.R343C	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1111
p.R343C	SLVL	haematopoietic and lymphoid tissue	COSMIC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1111
p.G346A	OVMIU	ovary	COSMIC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1944
p.E346V	MZ7-mel	skin	COSMIC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation rewiring degron network	0.1944
p.G352A	OVMIU	ovary	COSMIC	VFLFQE	LIG_APCC_ABBA_1	351:356	Mutation altering degron motif	0.754

Kaplan plot for ARHGEF3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF3

UniProt ID: Q9NR81

Entrez ID: 50650

Protein name: Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF3 in