DegronMD

Uniprot ID: Q9NR81

Source protein: Rho guanine nucleotide exchange factor 3

Source gene: ARHGEF3

Class: LIG_APCC_ABBA_1

Location: 351:356

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6537

ASA_SCORE: 26.5333

COIL: 0.2705

CONS_SCORE: 0.6922

DSS_SCORE: 0.0103

HELIX: 0.0347

FCONS_SCORE: 1.2612

RIG_SCORE: 0.9884

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D358E	TCGA-24-2030	OV	TCGA	VFLFQE	LIG_APCC_ABBA_1	0.2778
p.S363R	TCGA-AX-A1CE	UCEC	TCGA	VFLFQE	LIG_APCC_ABBA_1	0.1389
p.D362N	TCGA-EO-A22R	UCEC	TCGA	VFLFQE	LIG_APCC_ABBA_1	0.1667
p.D362N	SIDM00590	Oral Cavity Carcinoma	GDSC	VFLFQE	LIG_APCC_ABBA_1	0.1667
p.D362N	HSC-2	upper_aerodigestive_tract	COSMIC	VFLFQE	LIG_APCC_ABBA_1	0.1667
p.L349F	TCGA-FG-A6IZ	LGG	TCGA	VFLFQE	LIG_APCC_ABBA_1	0.2778
p.R343S	TCGA-FS-A1ZG	SKCM	TCGA	VFLFQE	LIG_APCC_ABBA_1	0.1111
p.R345W	DO8730	COAD	ICGC	VFLFQE	LIG_APCC_ABBA_1	0.1667
p.R345W	DO233908	GACA	ICGC	VFLFQE	LIG_APCC_ABBA_1	0.1667
p.V347L	DO23645	LUAD	ICGC	VFLFQE	LIG_APCC_ABBA_1	0.2222
p.L341P	DO229229	THCA	ICGC	VFLFQE	LIG_APCC_ABBA_1	0.0556
p.R343C	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VFLFQE	LIG_APCC_ABBA_1	0.1111
p.R343C	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	VFLFQE	LIG_APCC_ABBA_1	0.1111
p.G346A	OVMIU	ovary	COSMIC	VFLFQE	LIG_APCC_ABBA_1	0.1944
p.E346V	MZ7-mel	skin	COSMIC	VFLFQE	LIG_APCC_ABBA_1	0.1944
p.G352A	OVMIU	ovary	COSMIC	VFLFQE	LIG_APCC_ABBA_1	0.754

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR81	Rho guanine nucleotide exchange factor 3	LIG_APCC_ABBA_1	351:356	VFLFQE	APC,CDC20,FZR1	0.6537	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons