DegronMD - Q9NR83(SLC2A4RG)

FUNCTION: Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'. {ECO:0000269|PubMed:14625278, ECO:0000269|PubMed:14630949}.

GO - Biological processes (BP): regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]

GO - Cellular component (CC): cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PRLELPELL	DEG_APCC_DBOX_1	APC,CDC20,FZR1	SLC2A4 regulator	274:282	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R275L	DO228835	LICA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8428
p.R275C	DO229221	THCA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8301
p.R275H	DO233616	GACA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8244
p.L282P	ACH-000253	Colon/Colorectal Cancer	CCLE	PRLELPELL	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.6471
p.F273I	SIDM01148	Plasma Cell Myeloma	GDSC	PRLELPELL	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.3056
p.F273I	ACH-000050	Myeloma	CCLE	PRLELPELL	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.3056
p.A286S	DO233935	GACA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.2222
p.T266M	DO233267	GACA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1111
p.L291M	DO229272	THCA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0833

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No drug screening data available for this protein.

No resistance data available for this Degron.

Kaplan plot for SLC2A4RG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC2A4RG

UniProt ID: Q9NR83

Entrez ID: 56731

Protein name: SLC2A4 regulator (GLUT4 enhancer factor) (GEF) (Huntington disease gene regulatory region-binding protein 1) (HDBP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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No drug screening data available for this protein.

No resistance data available for this Degron.

Kaplan plot for SLC2A4RG in