DegronMD

Uniprot ID: Q9NR83

Source protein: SLC2A4 regulator

Source gene: SLC2A4RG

Class: DEG_APCC_DBOX_1

Location: 274:282

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9886

ASA_SCORE: 91.0889

COIL: 0.816

CONS_SCORE: 0.4615

DSS_SCORE: 0.5279

HELIX: 0.1349

FCONS_SCORE: 0.9912

RIG_SCORE: 0.702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T266M	DO233267	GACA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	0.1111
p.R275H	DO233616	GACA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	0.8244
p.A286S	DO233935	GACA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	0.2222
p.R275L	DO228835	LICA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	0.8428
p.L291M	DO229272	THCA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	0.0833
p.R275C	DO229221	THCA	ICGC	PRLELPELL	DEG_APCC_DBOX_1	0.8301
p.F273I	SIDM01148	Plasma Cell Myeloma	GDSC	PRLELPELL	DEG_APCC_DBOX_1	0.3056
p.F273I	ACH-000050	Myeloma	CCLE	PRLELPELL	DEG_APCC_DBOX_1	0.3056
p.L282P	ACH-000253	Colon/Colorectal Cancer	CCLE	PRLELPELL	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR83	SLC2A4 regulator	DEG_APCC_DBOX_1	274:282	PRLELPELL	APC,CDC20,FZR1	0.9886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons