DegronMD - Q9NRC1(ST7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S119R	TCGA-17-Z056	LUAD	TCGA	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.0556
p.E94K	TCGA-43-2578	LUSC	TCGA	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.1389
p.E94K	DO26662	LUSC	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.1389
p.S112P	TCGA-B5-A11E	UCEC	TCGA	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.25
p.S112P	DO41644	UCEC	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.25
p.L104F	TCGA-D6-6516	HNSC	TCGA	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.587
p.L104F	DO15623	HNSC	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.587
p.L101V	TCGA-G5-6233	READ	TCGA	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.5654
p.L101V	DO233835	GACA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.5654
p.L101V	DO36626	READ	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.5654
p.N117K	DO48404	BLCA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.1111
p.V108A	DO233254	GACA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.6936
p.I93V	DO228202	LICA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.1111
p.N111I	DO228815	LICA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.2778
p.R102L	DO228985	LICA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.8428
p.G107V	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.6421
p.G107V	ACH-000675	Lung Cancer	CCLE	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.6421
p.G107V	NCI-H1734	lung	COSMIC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.6421
p.R104W	HCC2998	large intestine	COSMIC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.8634
p.R107W	HCC2998	large intestine	COSMIC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.8634
p.R100W	HCC2998	large intestine	COSMIC	LRPLLGGVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.3056

Kaplan plot for ST7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ST7

UniProt ID: Q9NRC1

Entrez ID: 7982

Protein name: Suppressor of tumorigenicity 7 protein (Protein FAM4A1) (Protein HELG)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ST7 in