DegronMD

Uniprot ID: Q9NRC1

Source protein: Suppressor of tumorigenicity 7 protein

Source gene: ST7

Class: DEG_APCC_DBOX_1

Location: 101:109

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5858

ASA_SCORE: 54.8444

COIL: 0.7086

CONS_SCORE: 0.5418

DSS_SCORE: 0.3384

HELIX: 0.1516

FCONS_SCORE: 1.2204

RIG_SCORE: 0.7289

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S119R	TCGA-17-Z056	LUAD	TCGA	LRPLLGGVD	DEG_APCC_DBOX_1	0.0556
p.E94K	TCGA-43-2578	LUSC	TCGA	LRPLLGGVD	DEG_APCC_DBOX_1	0.1389
p.E94K	DO26662	LUSC	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	0.1389
p.S112P	TCGA-B5-A11E	UCEC	TCGA	LRPLLGGVD	DEG_APCC_DBOX_1	0.25
p.S112P	DO41644	UCEC	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	0.25
p.L104F	TCGA-D6-6516	HNSC	TCGA	LRPLLGGVD	DEG_APCC_DBOX_1	0.587
p.L104F	DO15623	HNSC	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	0.587
p.L101V	TCGA-G5-6233	READ	TCGA	LRPLLGGVD	DEG_APCC_DBOX_1	0.5654
p.L101V	DO233835	GACA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	0.5654
p.L101V	DO36626	READ	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	0.5654
p.N117K	DO48404	BLCA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	0.1111
p.V108A	DO233254	GACA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	0.6936
p.I93V	DO228202	LICA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	0.1111
p.N111I	DO228815	LICA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	0.2778
p.R102L	DO228985	LICA	ICGC	LRPLLGGVD	DEG_APCC_DBOX_1	0.8428
p.G107V	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	LRPLLGGVD	DEG_APCC_DBOX_1	0.6421
p.G107V	ACH-000675	Lung Cancer	CCLE	LRPLLGGVD	DEG_APCC_DBOX_1	0.6421
p.G107V	NCI-H1734	lung	COSMIC	LRPLLGGVD	DEG_APCC_DBOX_1	0.6421
p.R104W	HCC2998	large_intestine	COSMIC	LRPLLGGVD	DEG_APCC_DBOX_1	0.8634
p.R107W	HCC2998	large_intestine	COSMIC	LRPLLGGVD	DEG_APCC_DBOX_1	0.8634
p.R100W	HCC2998	large_intestine	COSMIC	LRPLLGGVD	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRC1	Suppressor of tumorigenicity 7 protein	DEG_APCC_DBOX_1	101:109	LRPLLGGVD	APC,CDC20,FZR1	0.5858	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons