DegronMD - Q9NRF8(CTPS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K92N	TCGA-B5-A0JY	UCEC	TCGA	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation blocking ubiquitination signal	0.5833
p.K92N	DO43041	UCEC	ICGC	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation blocking ubiquitination signal	0.5833
p.R76I	TCGA-B6-A0X5	BRCA	TCGA	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2222
p.R76I	DO2096	BRCA	ICGC	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2222
p.G91V	TCGA-D1-A17D	UCEC	TCGA	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1667
p.G91V	DO41746	UCEC	ICGC	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1667
p.E75D	TCGA-EO-A3AV	UCEC	TCGA	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.E75D	DO52412	UCEC	ICGC	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.I93T	TCGA-UF-A71B	HNSC	TCGA	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.I93T	DO52107	HNSC	ICGC	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.N87S	DO232028	LICA	ICGC	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2778
p.N86K	DO229025	LICA	ICGC	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.N86Y	DO231186	LUSC	ICGC	INLYKD	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons